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The aim of this study was to identify the <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> endotype clusters and investigate the inflammatory patterns associated with the different endotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 259 <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> patients and 20 control subjects were enrolled in this prospective study. Twelve clinical variables were analyzed using cluster analysis and five inflammatory variables were measured to investigate the inflammatory patterns associated with the different clusters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six endotype clusters of <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> were defined in the Chinese <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> patients. Patients in cluster 1 (38.6%) were diagnosed as allergic rhinitis (<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>) without asthma, and in cluster 2 (13.5%) as <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> with asthma, with all demonstrating positive results for local eosinophils and high levels of local and serum IgE. Similarly, patients in cluster 3 (18.6%) were diagnosed as nonallergic rhinitis with eosinophilia syndrome (<jats:styled-content style=\"fixed-case\">NARES<\/jats:styled-content>) without asthma and in cluster 5 (5.0%) as <jats:styled-content style=\"fixed-case\">NARES<\/jats:styled-content> with asthma, with all demonstrating positive results for local eosinophils, and negative results for both local and serum IgE. Patients in cluster 4 (4.6%) were diagnosed as local allergic rhinitis and showed positive results for local eosinophils and local IgE, but negative results for serum IgE, whereas patients in cluster 6 (19.7%) were diagnosed as idiopathic rhinitis because of high symptoms scores, but negative findings for local eosinophils, local IgE, and serum IgE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Chinese <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> patients may be clustered into six endotypes with different inflammatory patterns, which may help in delivering individualized treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.13640","type":"journal-article","created":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T19:49:01Z","timestamp":1540410541000},"page":"720-730","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Endotypes of chronic rhinitis: A cluster 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