{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T22:44:20Z","timestamp":1784241860344,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T00:00:00Z","timestamp":1543881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI13C0826"],"award-info":[{"award-number":["HI13C0826"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI15C2971"],"award-info":[{"award-number":["HI15C2971"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI17C0104"],"award-info":[{"award-number":["HI17C0104"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102017R1A2B2004043"],"award-info":[{"award-number":["NRF\u20102017R1A2B2004043"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2019,4]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Chitinase 3\u2010like 1 protein (CHI<\/jats:styled-content>3L1) (YKL<\/jats:styled-content>\u201040 in humans and breast regression protein [BRP<\/jats:styled-content>]\u201039 in mice) is required for optimal allergen sensitization and Th2 inflammation in various chronic inflammatory diseases including asthma. However, the role of CHI<\/jats:styled-content>3L1 in airway inflammation induced by respiratory viruses has not been investigated. The aim of this study was to investigate the relationship between CHI<\/jats:styled-content>3L1 and airway inflammation caused by respiratory syncytial virus (RSV<\/jats:styled-content>) infection.<\/jats:p><\/jats:sec>Methods<\/jats:title>We measured YKL<\/jats:styled-content>\u201040 levels in human nasopharyngeal aspirate (NPA<\/jats:styled-content>) from hospitalized children presenting with acute respiratory symptoms. Wild\u2010type (WT<\/jats:styled-content>) and BRP<\/jats:styled-content>\u201039 knockout (KO<\/jats:styled-content>) C57BL<\/jats:styled-content>\/6 mice were inoculated with live RSV<\/jats:styled-content> (A2 strain). Bronchoalveolar lavage fluid and lung tissue samples were obtained on day 7 after inoculation to assess lung inflammation, airway reactivity, and expression of cytokines and BRP<\/jats:styled-content>\u201039.<\/jats:p><\/jats:sec>Results<\/jats:title>In human subjects, YKL<\/jats:styled-content>\u201040 and IL<\/jats:styled-content>\u201013 levels in NPA<\/jats:styled-content> were higher in children with RSV<\/jats:styled-content> infection than in control subjects. Expression of BRP<\/jats:styled-content>\u201039 and Th2 cytokines, IL<\/jats:styled-content>\u201013 in particular, was increased following RSV<\/jats:styled-content> infection in mice. Airway\u00a0inflammation caused by RSV<\/jats:styled-content> infection was reduced in BRP<\/jats:styled-content>\u201039 KO<\/jats:styled-content> mice as compared to WT<\/jats:styled-content> mice. Th2 cytokine levels were not increased in the lungs of RSV<\/jats:styled-content>\u2010infected BRP<\/jats:styled-content>\u201039 KO<\/jats:styled-content> mice. BRP<\/jats:styled-content>\u201039 regulated M2 macrophage activation\u00a0in\u00a0RSV<\/jats:styled-content>\u2010infected mice. Additionally, treatment with anti\u2010CHI<\/jats:styled-content>3L1 antibody attenuated airway inflammation and Th2 cytokine production in RSV<\/jats:styled-content>\u2010infected WT<\/jats:styled-content> mice.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>These findings suggest that CHI<\/jats:styled-content>3L1 could contribute to airway inflammation induced by RSV<\/jats:styled-content> infection. CHI<\/jats:styled-content>3L1 could be a potential therapeutic\u00a0candidate for attenuating Th2\u2010associated immunopathology during RSV<\/jats:styled-content> infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.13661","type":"journal-article","created":{"date-parts":[[2018,11,7]],"date-time":"2018-11-07T09:49:52Z","timestamp":1541584192000},"page":"685-697","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Chitinase 3\u2010like 1 protein plays a critical role in respiratory syncytial virus\u2010induced airway inflammation"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5634-9709","authenticated-orcid":false,"given":"Min Jung","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology Brain Korea 21 PLUS Project for Medical Science Yonsei University College of Medicine Seoul Korea"},{"name":"Department of Pediatrics Severance Hospital Institute of Allergy Brain Korea 21 PLUS Project for Medical Science Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6696-7199","authenticated-orcid":false,"given":"Doo Hee","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Brain Korea 21 PLUS Project for Medical Science Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7112-7525","authenticated-orcid":false,"given":"Hye\u2010Ran","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Brain Korea 21 PLUS Project for Medical Science Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuk\u2010Young","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Brain Korea 21 PLUS Project for Medical Science Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Mo","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Brain Korea 21 PLUS Project for Medical Science Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Jin","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Brain Korea 21 PLUS Project for Medical Science Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4529-6135","authenticated-orcid":false,"given":"Kyung Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Severance Hospital Institute of Allergy Brain Korea 21 PLUS Project for Medical Science Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9604-3205","authenticated-orcid":false,"given":"Jeon Han","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Brain Korea 21 PLUS Project for Medical Science Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9514-3658","authenticated-orcid":false,"given":"Chun\u00a0Geun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology Brown University Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack A.","family":"Elias","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology Brown University Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2478-487X","authenticated-orcid":false,"given":"Myung Hyun","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Severance Hospital Institute of Allergy Brain Korea 21 PLUS Project for Medical Science Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5273-3113","authenticated-orcid":false,"given":"Jae Myun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Brain Korea 21 PLUS Project for Medical Science Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804877"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1413456"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30951-5"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2013.02.004"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e328360bd2e"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e32835eb6ef"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.121582"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2016.57.4.809"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa073600"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0708801"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20081271"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200912-1793OC"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2010-0081OC"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.05.017"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01209-08"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3038.2002.01093.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032226"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12462"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-014-0377-6"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1086\/592714"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2007-0186OC"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140440"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2010.2.1.20"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-012110-142250"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03886.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200809-1422OC"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.07.032"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2013.05.005"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-014-8540-1"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11262-006-0064-x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-012-0278-z"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2016.11.006"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2010.6"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.8879"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0913482"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.01.050"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1586\/erv.12.117"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-013-8368-9"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-2132"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201827"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2012.11.012"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.07.031"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000133"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2014-0366OC"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02014-09"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.13661","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.13661","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/all.13661","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.13661","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T19:44:50Z","timestamp":1694375090000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.13661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,4]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1111\/all.13661"],"URL":"https:\/\/doi.org\/10.1111\/all.13661","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,4]]},"assertion":[{"value":"2017-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}