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Conjunctivitis as an independent disorder has never been approached.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To identify distinct classes of allergic respiratory diseases using latent class analysis (<jats:styled-content style=\"fixed-case\">LCA<\/jats:styled-content>) and distinguish each class using classification and regression tree (<jats:styled-content style=\"fixed-case\">CART<\/jats:styled-content>) analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seven hundred and twenty\u2010eight adults from the Portuguese general population study <jats:styled-content style=\"fixed-case\">ICAR<\/jats:styled-content> had a structured medical interview combined with blood collection, skin prick tests, spirometry with bronchodilation, and exhaled nitric oxide. <jats:styled-content style=\"fixed-case\">LCA<\/jats:styled-content> was applied to 19 variables. The <jats:styled-content style=\"fixed-case\">CART<\/jats:styled-content> algorithm selected the most likely variables distinguishing <jats:styled-content style=\"fixed-case\">LCA<\/jats:styled-content>\u2010classes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A six\u2010class model was obtained. Class 1 (25%): nonallergic participants without bronchial or ocular symptoms. Classes 2 (22%) and 3 (11%): nasal and ocular (low levels) symptoms without nasal impairment, monosensitized (Class 2) or polysensitized (Class 3). Class 4 (13%): polysensitized participants with high levels of nasal and ocular symptoms, and nasal impairment. Classes 5 (16%) and 6 (14%): high level of nasal, bronchial and ocular symptoms with nasal impairment (non\u2010allergic or polysensitized, respectively). Participants in classes 5 and 6 had more bronchial exacerbations and unscheduled medical visits (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Ocular symptoms were significantly higher in classes with nasal impairment, compared to those without impairment (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) or no nasal symptom (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). <jats:styled-content style=\"fixed-case\">CART<\/jats:styled-content> highlighted ocular symptoms as the most relevant variable in distinguishing <jats:styled-content style=\"fixed-case\">LCA<\/jats:styled-content>\u2010classes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Novel severe phenotypes of participants with co\u2010occurrence of ocular, nasal and bronchial symptoms, and exacerbation\u2010prone were identified. The tree algorithm showed the importance of the ocular symptoms in the expression of allergic diseases phenotypes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.13670","type":"journal-article","created":{"date-parts":[[2018,11,17]],"date-time":"2018-11-17T20:18:24Z","timestamp":1542485904000},"page":"698-708","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Disentangling the heterogeneity of allergic respiratory diseases by latent class analysis reveals novel phenotypes"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0233-830X","authenticated-orcid":false,"given":"Rita","family":"Amaral","sequence":"first","affiliation":[{"name":"CINTESIS \u2010 Center for Health Technology and Services Research Faculty of Medicine University of Porto Porto Portugal"},{"name":"Department of Cardiovascular and Respiratory Sciences Porto Health School Porto 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