{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:27:11Z","timestamp":1790501231040,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T00:00:00Z","timestamp":1549497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["CRSII3_154488"],"award-info":[{"award-number":["CRSII3_154488"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030_144219"],"award-info":[{"award-number":["310030_144219"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030\u2010127356"],"award-info":[{"award-number":["310030\u2010127356"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030_144219"],"award-info":[{"award-number":["310030_144219"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Histamine is an important immunomodulator influencing both the innate and adaptive immune system. Certain host cells express the histidine decarboxylase enzyme (<jats:styled-content style=\"fixed-case\">HDC<\/jats:styled-content>), which is responsible for catalysing the decarboxylation of histidine to histamine. We and others have shown that bacterial strains can also express <jats:styled-content style=\"fixed-case\">HDC<\/jats:styled-content> and secrete histamine; however, the influence of bacterial\u2010derived histamine on the host immune responses distant to the gut is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The <jats:italic>Escherichia coli <\/jats:italic><jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>21 (<jats:italic>E\u00a0coli <\/jats:italic><jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>21) strain was genetically modified to express the <jats:italic>Morganella morganii<\/jats:italic> (<jats:italic>M\u00a0morganii<\/jats:italic>)\u2010derived <jats:styled-content style=\"fixed-case\">HDC<\/jats:styled-content> gene (<jats:italic>E\u00a0coli <\/jats:italic><jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>21_<jats:styled-content style=\"fixed-case\">HTW<\/jats:styled-content>). <jats:italic>E\u00a0coli <\/jats:italic><jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>21 and <jats:italic>E\u00a0coli <\/jats:italic><jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>21_<jats:styled-content style=\"fixed-case\">HTW<\/jats:styled-content> were gavaged to ovalbumin (<jats:styled-content style=\"fixed-case\">OVA<\/jats:styled-content>) sensitized and challenged mice to investigate the effect of bacterial\u2010derived histamine on lung inflammatory responses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Oral administration of <jats:italic>E\u00a0coli <\/jats:italic><jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>21_<jats:styled-content style=\"fixed-case\">HTW<\/jats:styled-content>, which is able to secrete histamine, to wild\u2010type mice reduced lung eosinophilia and suppressed ex\u00a0vivo <jats:styled-content style=\"fixed-case\">OVA<\/jats:styled-content>\u2010stimulated cytokine secretion from lung cells in the <jats:styled-content style=\"fixed-case\">OVA<\/jats:styled-content> respiratory inflammation mouse model. In histamine receptor 2 (H2R)\u2010deficient mice, administration of histamine\u2010secreting bacteria also reduced inflammatory cell numbers in bronchoalveolar lavage (<jats:styled-content style=\"fixed-case\">BAL<\/jats:styled-content>). However, the suppressive effect of bacterial\u2010derived histamine on <jats:styled-content style=\"fixed-case\">BAL<\/jats:styled-content> inflammation was lost in <jats:styled-content style=\"fixed-case\">HDC<\/jats:styled-content>\u2010deficient mice. This loss of activity was associated with increased expression of histamine degrading enzymes and reduced histamine receptor expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Histamine secretion from bacteria within the gut can have immunological consequences at distant mucosal sites, such as within the lung. These effects are influenced by host histamine receptor expression and the expression of histamine degrading enzymes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.13709","type":"journal-article","created":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T19:53:35Z","timestamp":1545940415000},"page":"899-909","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Bacterial secretion of histamine within the gut influences immune responses within the lung"],"prefix":"10.1111","volume":"74","author":[{"given":"Weronika","family":"Barcik","sequence":"first","affiliation":[{"name":"Swiss Institute of Allergy and Asthma Research (SIAF) University of Zurich Davos Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Pugin","sequence":"additional","affiliation":[{"name":"Swiss Institute of Allergy and Asthma Research (SIAF) University of Zurich Davos Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Sabat\u00e9","family":"Bresc\u00f3","sequence":"additional","affiliation":[{"name":"Swiss Institute of Allergy and Asthma Research (SIAF) University of Zurich Davos Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Westermann","sequence":"additional","affiliation":[{"name":"Swiss Institute of Allergy and Asthma Research (SIAF) University of Zurich Davos Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8967-3866","authenticated-orcid":false,"given":"Arturo","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"Swiss Institute of Allergy and Asthma Research (SIAF) University of Zurich Davos Switzerland"},{"name":"Christine K\u00fchne\u2010Center for Allergy Research and Education Davos Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Groeger","sequence":"additional","affiliation":[{"name":"Alimentary Health Pharma Davos (AHPD) Davos Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dries","family":"Van Elst","sequence":"additional","affiliation":[{"name":"Swiss Institute of Allergy and Asthma Research (SIAF) University of Zurich Davos Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Sokolowska","sequence":"additional","affiliation":[{"name":"Swiss Institute of Allergy and Asthma Research (SIAF) University of Zurich Davos Switzerland"},{"name":"Christine K\u00fchne\u2010Center for Allergy Research and Education Davos Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Krawczyk","sequence":"additional","affiliation":[{"name":"Swiss Institute of Allergy and Asthma Research (SIAF) University of Zurich Davos Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remo","family":"Frei","sequence":"additional","affiliation":[{"name":"Swiss Institute of Allergy and Asthma Research (SIAF) University of Zurich Davos Switzerland"},{"name":"Christine K\u00fchne\u2010Center for Allergy Research and Education Davos Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Ferstl","sequence":"additional","affiliation":[{"name":"Swiss Institute of Allergy and Asthma Research (SIAF) University of Zurich Davos Switzerland"},{"name":"Christine K\u00fchne\u2010Center for Allergy Research and Education Davos Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Wawrzyniak","sequence":"additional","affiliation":[{"name":"Swiss Institute of Allergy and Asthma Research (SIAF) University of Zurich Davos Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Altunbulakli","sequence":"additional","affiliation":[{"name":"Swiss Institute of Allergy and Asthma Research (SIAF) University of Zurich Davos Switzerland"},{"name":"Christine K\u00fchne\u2010Center for Allergy Research and Education Davos Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cezmi A.","family":"Akdis","sequence":"additional","affiliation":[{"name":"Swiss Institute of Allergy and Asthma Research (SIAF) University of Zurich Davos Switzerland"},{"name":"Christine K\u00fchne\u2010Center for Allergy Research and Education Davos Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4705-3583","authenticated-orcid":false,"given":"Liam","family":"O'Mahony","sequence":"additional","affiliation":[{"name":"Swiss Institute of Allergy and Asthma Research (SIAF) University of Zurich Davos Switzerland"},{"name":"Departments of Medicine and Microbiology APC Microbiome Ireland National University of Ireland Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.11.037"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-017-0533-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40629-017-0042-y"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12948-017-0076-1"},{"key":"e_1_2_8_6_1","volume-title":"Chronic Asthma: management","author":"(UK) NGA","year":"2017"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-8056-4_6"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2017.08.011"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.06.051"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddmod.2016.06.003"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjm.2016.01.016"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02531-10"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.12765"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2013.03.054"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2012.10.138"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-765X.2007.02207.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1605(00)00296-8"},{"key":"e_1_2_8_18_1","first-page":"1","article-title":"Histamine food poisonings: a systematic review and meta\u2010analysis","volume":"58","author":"Colombo FM","year":"2016","journal-title":"Crit Rev Food Sci Nutr"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-015-8467-x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.05.049"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2741\/3914"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12330"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.01.013"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13227"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.04.034"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01358-15"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000825"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(83)90092-2"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2015-9095"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.2001.1409"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.4103\/1817-1737.58958"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-2077"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20140625"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.09.031"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13634"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.04.060"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200806-951OC"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40733-017-0037-y"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2004.10.010"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci4020031"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028X.JFP-15-313"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fm.2016.05.012"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/16512235.2017.1353881"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-1008com"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0162-3109(00)00268-X"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.13709","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.13709","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/all.13709","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.13709","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T14:45:12Z","timestamp":1694357112000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.13709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,7]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1111\/all.13709"],"URL":"https:\/\/doi.org\/10.1111\/all.13709","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,7]]},"assertion":[{"value":"2018-03-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}