{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:32:52Z","timestamp":1790652772102,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,2,17]],"date-time":"2019-02-17T00:00:00Z","timestamp":1550361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["ARADyAL RD16\/0006\/0001"],"award-info":[{"award-number":["ARADyAL RD16\/0006\/0001"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PI15\/01206"],"award-info":[{"award-number":["PI15\/01206"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["RIRAAF RD12\/0013\/0001"],"award-info":[{"award-number":["RIRAAF RD12\/0013\/0001"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An accurate diagnosis of \u03b2\u2010lactam (<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>) allergy can reduce patient morbidity and mortality. Our aim was to investigate the availability of <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> reagents, their use and test procedures in different parts of Europe, as well as any differences in the diagnostic workups for evaluating subjects with <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> hypersensitivity. A survey was emailed to all members of the <jats:styled-content style=\"fixed-case\">EAACI<\/jats:styled-content> Drug Allergy Interest Group (<jats:styled-content style=\"fixed-case\">DAIG<\/jats:styled-content>) between February and April 2016, and the questionnaire was meant to study the management of suspected <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> hypersensitivity. The questionnaire was emailed to 82 <jats:styled-content style=\"fixed-case\">DAIG<\/jats:styled-content> centres and answered by 57. Amoxicillin alone or combined to clavulanic acid were the most commonly involved <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> except in the Danish centre, where penicillin V was the most frequently suspected <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>. All centres performed an allergy workup in subjects with histories of hypersensitivity to <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>: 53 centres (93%) followed <jats:styled-content style=\"fixed-case\">DAIG<\/jats:styled-content> guidelines, two national guidelines and two local guidelines. However, there were deviations from <jats:styled-content style=\"fixed-case\">DAIG<\/jats:styled-content> recommendations concerning allergy tests, especially drug provocation tests. A significant heterogeneity exists in current practice not only among countries, but also among centres within the same country. This suggests the need to re\u2010evaluate, update and standardize protocols on the management of patients with suspected <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> allergy.<\/jats:p>","DOI":"10.1111\/all.13721","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T09:55:36Z","timestamp":1547459736000},"page":"1052-1062","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["A EAACI drug allergy interest group survey on how European allergy specialists deal with \u03b2\u2010lactam allergy"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5228-471X","authenticated-orcid":false,"given":"Maria Jose","family":"Torres","sequence":"first","affiliation":[{"name":"Allergy Unit Regional University Hospital of Malaga\u2010IBIMA\u2010UMA Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8654-513X","authenticated-orcid":false,"given":"Gulfem Elif","family":"Celik","sequence":"additional","affiliation":[{"name":"Department of Immunology and Allergy Ankara University School of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Whitaker","sequence":"additional","affiliation":[{"name":"Regional Adult Cystic Fibrosis Unit St James's Hospital Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1354-6072","authenticated-orcid":false,"given":"Marina","family":"Atanaskovic\u2010Markovic","sequence":"additional","affiliation":[{"name":"University Children's hospital Medical Faculty University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annick","family":"Barbaud","sequence":"additional","affiliation":[{"name":"Dermatology and Allergology Department Tenon Hospital (AP\u2010HP) Sorbonne Universities UPMC University Paris 06 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6683-3975","authenticated-orcid":false,"given":"Andreas","family":"Bircher","sequence":"additional","affiliation":[{"name":"Allergology University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Blanca","sequence":"additional","affiliation":[{"name":"Allergy Service Infanta Leonor University Hospital Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2775-3681","authenticated-orcid":false,"given":"Knut","family":"Brockow","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Biederstein Technische Universit\u00e4t M\u00fcnchen Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Christoph","family":"Caubet","sequence":"additional","affiliation":[{"name":"Pediatric allergy unit Geneva University Hospital Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefina Rodrigues","family":"Cernadas","sequence":"additional","affiliation":[{"name":"Department of Allergy and Immunology Hospital de S Jo\u00e3o University School of Medicine Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1558-1966","authenticated-orcid":false,"given":"Anca","family":"Chiriac","sequence":"additional","affiliation":[{"name":"Division of Allergy Department of Pulmonology H\u00f4pital Arnaud de Villeneuve University Hospital of Montpellier Montpellier France"},{"name":"UMRS 1136 Equipe \u2010 EPAR \u2010 IPLESP Sorbonne Universit\u00e9s UPMC Univ Paris 06 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7827-7964","authenticated-orcid":false,"given":"Pascal","family":"Demoly","sequence":"additional","affiliation":[{"name":"Division of Allergy Department of Pulmonology H\u00f4pital Arnaud de Villeneuve University Hospital of Montpellier Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7777-4501","authenticated-orcid":false,"given":"Lene Heise","family":"Garvey","sequence":"additional","affiliation":[{"name":"Allergy Clinic Department of Dermatology and Allergy Herlev and Gentofte Hospital University of Copenhagen Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans F.","family":"Merk","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology RWTH Aachen University Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Mosbech","sequence":"additional","affiliation":[{"name":"Allergy Clinic Department of Dermatology and Allergy Herlev and Gentofte Hospital University of Copenhagen Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0141-6361","authenticated-orcid":false,"given":"Alla","family":"Nakonechna","sequence":"additional","affiliation":[{"name":"Allergy and Immunology Clinic Royal Liverpool and Broadgreen University Hospitals Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Romano","sequence":"additional","affiliation":[{"name":"Allergy Unit Presidio Columbus Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.11.047"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12350"},{"key":"e_1_2_10_4_1","first-page":"363","article-title":"Drug hypersensitivity reactions: response patterns, drug involved, and temporal variations in a large series of patients","volume":"22","author":"Dona I","year":"2012","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.09.021"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2003.01638.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70097-1"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2008.12.034"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1288"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2014-202438"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2016.04.021"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2003.00280.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00678.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01924.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1254"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12195"},{"key":"e_1_2_10_17_1","first-page":"143","article-title":"Trends in Hypersensitivity Drug Reactions: more drugs, More Response Patterns, More Heterogeneity","volume":"24","author":"Do\u00f1a I","year":"2014","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.03.012"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.11.032"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12636"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.02317.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-3178"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02043.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.06.052"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.12.995"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.03.012"},{"issue":"6","key":"e_1_2_10_27_1","first-page":"vi25","article-title":"European Surveillance of Antimicrobial Consumption (ESAC): outpatient cephalosporin use in Europe (1997\u20102009)","volume":"66","author":"Versporten A","year":"2011","journal-title":"J Antimicrob Chemother"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12134"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12886"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1992.00400170105020"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2001.00089.x"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60882-4"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08975.x"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2016.1191319"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12468"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2013.07.007"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12142"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03834.x"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02318.x"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2001.00995.x"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2002.01305.x"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01268.x"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03219.x"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121857"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.02110.x"},{"key":"e_1_2_10_46_1","first-page":"473","article-title":"Diagnosis of clavulanic acid allergy using basophil activation and leukotriene release by basophils","volume":"18","author":"Longo N","year":"2008","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2003.00279.x"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.02.024"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.13721","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.13721","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T08:37:37Z","timestamp":1694335057000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.13721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,17]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/all.13721"],"URL":"https:\/\/doi.org\/10.1111\/all.13721","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,17]]},"assertion":[{"value":"2018-04-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}