{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T22:53:12Z","timestamp":1772059992088,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T00:00:00Z","timestamp":1552521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although pollen\u2010related food allergy occurs in all European populations, lipid transfer protein (<jats:styled-content style=\"fixed-case\">LTP<\/jats:styled-content>) allergy is considered to manifest mainly in Mediterranean countries. We aimed to characterize adults presenting with <jats:styled-content style=\"fixed-case\">LTP<\/jats:styled-content> allergy in a northern European country.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The clinical history and sensitization patterns of subjects born and residing in the United Kingdom (<jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>), with a prior diagnosis of <jats:styled-content style=\"fixed-case\">LTP<\/jats:styled-content> allergy and sensitization to the peach <jats:styled-content style=\"fixed-case\">LTP<\/jats:styled-content> allergen Pru p 3, were compared to <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> subjects with pollen food syndrome (<jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>). The sensitization patterns were also evaluated against a matched cohort of Italian subjects diagnosed with <jats:styled-content style=\"fixed-case\">LTP<\/jats:styled-content> allergy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>None of the 15 <jats:styled-content style=\"fixed-case\">UK PFS<\/jats:styled-content> subjects had a positive <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> to <jats:styled-content style=\"fixed-case\">LTP<\/jats:styled-content>\u2010enriched peach reagent, compared to 91% of the 35 <jats:styled-content style=\"fixed-case\">UK LTP<\/jats:styled-content> subjects. The <jats:styled-content style=\"fixed-case\">UK LTP<\/jats:styled-content> cohort were also more likely to have positive skin prick tests to cabbage, lettuce and mustard and sensitization to the <jats:styled-content style=\"fixed-case\">LTP<\/jats:styled-content> allergens in peach, walnut, mugwort and plane tree These sensitization patterns to individual allergens were not significantly different to those obtained from the Italian <jats:styled-content style=\"fixed-case\">LTP<\/jats:styled-content> subjects, with significant correlations between Pru p 3 and the <jats:styled-content style=\"fixed-case\">LTP<\/jats:styled-content> allergens in peanuts, walnuts, plane tree and mugwort in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Native <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> subjects with <jats:styled-content style=\"fixed-case\">LTP<\/jats:styled-content> allergy are not dissimilar to those with <jats:styled-content style=\"fixed-case\">LTP<\/jats:styled-content> allergy in southern Europe. Testing to <jats:styled-content style=\"fixed-case\">LTP<\/jats:styled-content>\u2010enriched peach <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> reagent and\/or <jats:styled-content style=\"fixed-case\">LTP<\/jats:styled-content> allergens in peach, walnut, mugwort and plane tree may enhance diagnostic accuracy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.13747","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T14:48:01Z","timestamp":1550155681000},"page":"1340-1351","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Lipid Transfer Protein allergy in the United Kingdom: Characterization and comparison with a matched Italian cohort"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3629-4293","authenticated-orcid":false,"given":"Isabel J.","family":"Skypala","sequence":"first","affiliation":[{"name":"Royal Brompton &amp; Harefield NHS Foundation Trust London UK"},{"name":"Imperial College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0658-2449","authenticated-orcid":false,"given":"Lorenzo","family":"Cecchi","sequence":"additional","affiliation":[{"name":"SOS Allergy and Immunology USL Toscana Centro Prato Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3425-3463","authenticated-orcid":false,"given":"Mohamed H.","family":"Shamji","sequence":"additional","affiliation":[{"name":"Imperial College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9391-9168","authenticated-orcid":false,"given":"Enrico","family":"Scala","sequence":"additional","affiliation":[{"name":"Istituto Dermopatico dell'Immacolata IDI\u2010IRCCS Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4518-3093","authenticated-orcid":false,"given":"Stephen","family":"Till","sequence":"additional","affiliation":[{"name":"Guy's &amp; St Thomas\u2019 NHS Foundation Trust London UK"},{"name":"King's College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.04.006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12104"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04132.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03759.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.02018.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0300906"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1515\/BC.1999.167"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.05.012"},{"key":"e_1_2_7_10_1","first-page":"398","article-title":"The evaluation of peach lipid transfer protein Pru p 3 as a marker of severe plant food allergy in a UK adult clinic population","volume":"65","author":"Skypala I","year":"2010","journal-title":"Allergy"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.01968.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.05.013"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12429"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.01.026"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2007.01.030"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac102201m"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2014.02.076"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12666"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000087352"},{"key":"e_1_2_7_20_1","first-page":"129","article-title":"Lipid transfer protein cross\u2010reactivity assessed in\u00a0vivo and in\u00a0vitro in the office: pros and cons","volume":"21","author":"Asero R","year":"2011","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.12.1949"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.09.010"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000445893"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13151"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.06.016"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000446156"},{"key":"e_1_2_7_27_1","first-page":"106","article-title":"Allergy to peanut lipid transfer protein (LTP): frequency and cross\u2010reactivity between peanut and peach LTP","volume":"41","author":"Romano A","year":"2009","journal-title":"Eur Ann Allergy Clin Immunol"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2012.04071.x"},{"key":"e_1_2_7_29_1","first-page":"196","article-title":"Tomato nsLTP as an \u201cIn Vivo\u201d diagnostic tool: sensitization in a mediterranean population","volume":"25","author":"L\u00f3pez\u2010Matas MA","year":"2015","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_7_30_1","first-page":"183","article-title":"Hypersensitivity to tomato (Lycopersicon esculentum) in peach\u2010allergic patients: rPrup 3 and rPrup 1 are predictive of symptom severity","volume":"25","author":"Mascheri A","year":"2015","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000086332"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi901939z"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00876.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf9022367"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.5114\/pdia.2015.53321"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13053"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1159\/000102615"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1159\/000053671"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-012-8338-7"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12635"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2013-0027"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.07.015"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.08.005"},{"key":"e_1_2_7_44_1","first-page":"283","article-title":"Do skin prick test and in\u00a0vitro techniques diagnose sensitization to peach lipid transfer protein and profilin equally well in allergy to plant food and pollen?","volume":"25","author":"Goikoetxea MJ","year":"2015","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050799"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02121.x"},{"key":"e_1_2_7_47_1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/ddg.12731","article-title":"Measurement of health\u2010related quality of life in adult patients with birch pollen\u2010associated food allergy","volume":"14","author":"Beyer S","year":"2016","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2013.09.012"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12028"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.13747","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.13747","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/all.13747","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.13747","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T19:52:41Z","timestamp":1694289161000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.13747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,14]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1111\/all.13747"],"URL":"https:\/\/doi.org\/10.1111\/all.13747","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,14]]},"assertion":[{"value":"2018-10-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}