{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:54:35Z","timestamp":1792497275435,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T00:00:00Z","timestamp":1554940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["(Infrafrontier grant 01KX1012)"],"award-info":[{"award-number":["(Infrafrontier grant 01KX1012)"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2019,8]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Allergen\u2010specific immunotherapy (\n AIT<\/jats:styled-content>\n ) is the only causal treatment for allergy. However, success rates vary depending on the type of allergy and disease background of the patient. Hence, strategies targeting an increased therapeutic efficacy are urgently needed. Here, the effects of blockade of\n IL<\/jats:styled-content>\n \u20104 and\n IL<\/jats:styled-content>\n \u201013 signaling on different phases of\n AIT<\/jats:styled-content>\n were addressed.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The impact of the recombinantly produced\n IL<\/jats:styled-content>\n \u20104 and\n IL<\/jats:styled-content>\n \u201013 antagonist\n IL<\/jats:styled-content>\n \u20104 mutein (\n IL<\/jats:styled-content>\n \u20104M) on allergic sensitization and\n AIT<\/jats:styled-content>\n outcome in experimental allergic asthma were analyzed in a murine model. The effects of\n IL<\/jats:styled-content>\n \u20104M administration were assessed prior\/during sensitization, immediately after\n AIT<\/jats:styled-content>\n under allergen challenge, and two weeks post\u2010treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Intervention with\n IL<\/jats:styled-content>\n \u20104M prior\/during sensitization led to strong induction of IgG1, IgG2a, IgG2b, and IgG3, decrease of specific and total IgE, as well as of\n IL<\/jats:styled-content>\n \u20105 in serum. Similar effects on the serum immunoglobulin levels were observed immediately after\n IL<\/jats:styled-content>\n 4M\u2010supplemented\n AIT<\/jats:styled-content>\n during allergen challenge. Additionally,\n IL<\/jats:styled-content>\n 4M markedly suppressed type\u20102 cytokine secretion of splenocytes beyond the effect of\n AIT<\/jats:styled-content>\n alone. These effects were equaled to those of\n AIT<\/jats:styled-content>\n alone two weeks post\u2010treatment. Intriguingly, here,\n IL<\/jats:styled-content>\n \u20104M induced a sustained decrease of Th2\u2010biased Tregs (\n ST<\/jats:styled-content>\n 2\n +<\/jats:sup>\n FOXP<\/jats:styled-content>\n 3\n +<\/jats:sup>\n GATA<\/jats:styled-content>\n 3\n intermediate<\/jats:sup>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n IL<\/jats:styled-content>\n \u20104 and\n IL<\/jats:styled-content>\n \u201013 blockade during experimental\n AIT<\/jats:styled-content>\n demonstrates beneficial effects on immunological key parameters such as immunoglobulin and cytokine secretion immediately after\n AIT<\/jats:styled-content>\n . Although two weeks later these effects were dropped to those of\n AIT<\/jats:styled-content>\n alone, the number of potentially disease\u2010triggering Th2\u2010biased Tregs was further significantly decreased by\n IL<\/jats:styled-content>\n \u20104M treatment. Hence,\n IL<\/jats:styled-content>\n \u20104\/\n IL<\/jats:styled-content>\n 13\u2010targeting therapies prime the immune memory in therapy success\u2010favoring manner.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/all.13759","type":"journal-article","created":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T08:15:18Z","timestamp":1551687318000},"page":"1549-1560","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["IL<\/scp>\n \u20104 receptor \u03b1 blockade prevents sensitization and alters acute and long\u2010lasting effects of allergen\u2010specific immunotherapy of murine allergic asthma"],"prefix":"10.1111","volume":"74","author":[{"given":"D.","family":"Russkamp","sequence":"first","affiliation":[{"name":"Center of Allergy and Environment (ZAUM) Technical University of Munich and Helmholtz Center Munich Member of the German Center of Lung Research (DZL) Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Aguilar\u2010Pimentel","sequence":"additional","affiliation":[{"name":"German Mouse Clinic Institute of Experimental Genetics Helmholtz Center Munich Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Alessandrini","sequence":"additional","affiliation":[{"name":"Center of Allergy and Environment (ZAUM) Technical University of Munich and Helmholtz Center Munich Member of the German Center of Lung Research (DZL) Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Gailus\u2010Durner","sequence":"additional","affiliation":[{"name":"German Mouse Clinic Institute of Experimental Genetics Helmholtz Center Munich Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Fuchs","sequence":"additional","affiliation":[{"name":"German Mouse Clinic Institute of Experimental Genetics Helmholtz Center Munich Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Ohnmacht","sequence":"additional","affiliation":[{"name":"Center of Allergy and Environment (ZAUM) Technical University of Munich and Helmholtz Center Munich Member of the German Center of Lung Research (DZL) Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Chaker","sequence":"additional","affiliation":[{"name":"Center of Allergy and Environment (ZAUM) Technical University of Munich and Helmholtz Center Munich Member of the German Center of Lung Research (DZL) Munich Germany"},{"name":"Department of Otolaryngology Klinikum rechts der Isar Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. H.","family":"de Angelis","sequence":"additional","affiliation":[{"name":"German Mouse Clinic Institute of Experimental Genetics Helmholtz Center Munich Neuherberg Germany"},{"name":"Chair of Experimental Genetics School of Life Science Weihenstephan Technical University of Munich Freising Germany"},{"name":"German Center for Diabetes Research (DZD) Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ollert","sequence":"additional","affiliation":[{"name":"Luxembourg Institute of Health (LIH) Esch\u2010sur\u2010Alzette Luxembourg"},{"name":"Department of Dermatology and Allergy Center Odense Research Center for Anaphylaxis University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. B.","family":"Schmidt\u2010Weber","sequence":"additional","affiliation":[{"name":"Center of Allergy and Environment (ZAUM) Technical University of Munich and Helmholtz Center Munich Member of the German Center of Lung Research (DZL) Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5649-1078","authenticated-orcid":false,"given":"S.","family":"Blank","sequence":"additional","affiliation":[{"name":"Center of Allergy and Environment (ZAUM) Technical University of Munich and Helmholtz Center Munich Member of the German Center of Lung Research (DZL) Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2017.1334745"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215117002110"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.02384.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000327546"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0178563"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000216"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-7022-2-8"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200322919"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12966"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1527"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.05.014"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.168.3.853"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0050329"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20161104"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.01.017"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2004.06.008"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-308337"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30184-X"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1314768"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30307-5"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.12136"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.3.1480"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61600-6"},{"issue":"5","key":"e_1_2_9_25_1","first-page":"455","article-title":"Elevation of soluble IL\u20102 receptor and IL\u20104, and nonelevation of IFN\u2010gamma in sera from patients with allergic asthma","volume":"71","author":"Hashimoto S","year":"1993","journal-title":"Ann Allergy"},{"issue":"2","key":"e_1_2_9_26_1","first-page":"67","article-title":"Association of the expression of IL\u20104 and IL\u201013 genes, IL\u20104 and IgE serum levels with allergic asthma","volume":"6","author":"Tavakkol Afshari J","year":"2007","journal-title":"Iran J Allergy Asthma Immunol"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198902023200502"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.09.016"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0501701102"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00186-8"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830261216"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.19.4.3112m"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000096610"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270009341183"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-018-0370-9"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.03.013"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1948049"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200425719"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.06.025"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.4.1344"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-3079"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.1.109"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.10.6158"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.02.004"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161507"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.01.015"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.06.028"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.13759","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.13759","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/all.13759","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.13759","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T15:07:10Z","timestamp":1694272030000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.13759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,11]]},"references-count":46,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1111\/all.13759"],"URL":"https:\/\/doi.org\/10.1111\/all.13759","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,11]]},"assertion":[{"value":"2019-02-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}