{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:38:38Z","timestamp":1761676718719,"version":"3.40.5"},"reference-count":79,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T00:00:00Z","timestamp":1554854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011313","name":"Tokyo Biochemical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Coconut oil is used as a dietary oil worldwide, and its healthy effects are recognized by the fact that coconut oil is easy to digest, helps in weight management, increases healthy cholesterol, and provides instant energy. Although topical application of coconut oil is known to reduce skin infection and inflammation, whether dietary coconut oil has any role in decreasing skin inflammation is unknown. In this study, we showed the impact of dietary coconut oil in allergic skin inflammation by using a mouse model of contact hypersensitivity (CHS). Mice maintained on coconut oil showed amelioration of skin inflammation and increased levels of cis\u20105, 8, 11\u2010eicosatrienoic acid (mead acid) in serum. Intraperitoneal injection of mead acid inhibited CHS and reduced the number of neutrophils infiltrating to\u00a0the skin. Detailed mechanistic studies unveiled that mead acid inhibited the directional migration of neutrophils by inhibiting the filamentous actin polymerization and leukotriene B<jats:sub>4<\/jats:sub> production required for secondary recruitment of neutrophils. Our findings provide valuable insights into the preventive roles of coconut oil and mead acid against skin inflammation, thereby offering attractive therapeutic possibilities.<\/jats:p>","DOI":"10.1111\/all.13762","type":"journal-article","created":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T01:15:41Z","timestamp":1551921341000},"page":"1522-1532","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Dietary coconut oil ameliorates skin contact hypersensitivity through mead acid production in mice"],"prefix":"10.1111","volume":"74","author":[{"given":"Prabha","family":"Tiwari","sequence":"first","affiliation":[{"name":"Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research and Laboratory of Gut Environmental System National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN) Ibaraki\u2010city, Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Nagatake","sequence":"additional","affiliation":[{"name":"Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research and Laboratory of Gut Environmental System National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN) Ibaraki\u2010city, Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So\u2010ichiro","family":"Hirata","sequence":"additional","affiliation":[{"name":"Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research and Laboratory of Gut Environmental System National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN) Ibaraki\u2010city, Osaka Japan"},{"name":"Department of Microbiology and Immunology Kobe University Graduate School of Medicine Kobe\u2010city, Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kento","family":"Sawane","sequence":"additional","affiliation":[{"name":"Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research and Laboratory of Gut Environmental System National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN) Ibaraki\u2010city, Osaka Japan"},{"name":"Graduate School of Pharmaceutical Sciences Osaka University Suita\u2010city, Osaka Japan"},{"name":"Innovation Center Nippon Flour Mills Co., Ltd Atsugi-city, Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azusa","family":"Saika","sequence":"additional","affiliation":[{"name":"Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research and Laboratory of Gut Environmental System National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN) Ibaraki\u2010city, Osaka Japan"},{"name":"Graduate School of Pharmaceutical Sciences Osaka University Suita\u2010city, Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Shibata","sequence":"additional","affiliation":[{"name":"Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research and Laboratory of Gut Environmental System National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN) Ibaraki\u2010city, Osaka Japan"},{"name":"Graduate School of Pharmaceutical Sciences Osaka University Suita\u2010city, Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakiko","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research and Laboratory of Gut Environmental System National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN) Ibaraki\u2010city, Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kyoto University Graduate School of Medicine Kyoto-city, Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Adachi","sequence":"additional","affiliation":[{"name":"Laboratory of Proteome Research NIBIOHN Ibaraki\u2010city, Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Abe","sequence":"additional","affiliation":[{"name":"Laboratory of Proteome Research NIBIOHN Ibaraki\u2010city, Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Isoyama","sequence":"additional","affiliation":[{"name":"Laboratory of Proteome Research NIBIOHN Ibaraki\u2010city, Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Tomonaga","sequence":"additional","affiliation":[{"name":"Laboratory of Proteome Research NIBIOHN Ibaraki\u2010city, Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kiyono","sequence":"additional","affiliation":[{"name":"International Research and Development Center for Mucosal Vaccines The Institute of Medical Science, The University of Tokyo Minato-ku, Tokyo Japan"},{"name":"Department of Immunology, Graduate School of Medicine Chiba University Chiba\u2010city, Chiba Japan"},{"name":"Division of Gastroenterology, Department of Medicine University of California, San Diego (UCSD) San Diego California"},{"name":"CU\u2010UCSD Center for Mucosal Immunology, Allergy and Vaccines (cMAV) UCSD San Diego California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Kabashima","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kyoto University Graduate School of Medicine Kyoto-city, Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4901-1125","authenticated-orcid":false,"given":"Jun","family":"Kunisawa","sequence":"additional","affiliation":[{"name":"Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research and Laboratory of Gut Environmental System National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN) Ibaraki\u2010city, Osaka Japan"},{"name":"Department of Microbiology and Immunology Kobe University Graduate School of Medicine Kobe\u2010city, Hyogo Japan"},{"name":"Graduate School of Pharmaceutical Sciences Osaka University Suita\u2010city, Osaka Japan"},{"name":"International Research and Development Center for Mucosal Vaccines The Institute of Medical Science, The University of Tokyo Minato-ku, Tokyo Japan"},{"name":"Graduate School of Medicine and Graduate School of Dentistry Osaka University Suita\u2010city, Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-13-0397"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2009.12.002"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.60.7"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607115595980"},{"issue":"4","key":"e_1_2_9_6_1","first-page":"231","article-title":"Essential fatty acids and human brain","volume":"18","author":"Chang CY","year":"2009","journal-title":"Acta Neurol Taiwan"},{"issue":"5","key":"e_1_2_9_7_1","first-page":"48","article-title":"The usefulness of topical application of essential fatty acids (EFA) to prevent pressure ulcers","volume":"43","author":"Declair V","year":"1997","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.25.050304.092610"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8010023"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-003-1074-0"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-3322(02)00253-6"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32253-5"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/539426"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/71.1.171S"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2015.00052"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(01)00576-7"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu2030355"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20042031"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2010.08.002"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13197-010-0225-8"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i5796"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.3.417"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2008-14202"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2016-000467"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(97)01143-0"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.12.123"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.5713\/ajas.14.0328"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1992.186"},{"issue":"5","key":"e_1_2_9_29_1","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.4049\/jimmunol.145.5.1523","article-title":"Manipulation of the acute inflammatory response by dietary polyunsaturated fatty acid modulation","volume":"145","author":"Lefkowith JB","year":"1990","journal-title":"J Immunol"},{"issue":"10","key":"e_1_2_9_30_1","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.4049\/jimmunol.143.10.3192","article-title":"The antiinflammatory effects of essential fatty acid deficiency in experimental glomerulonephritis. The modulation of macrophage migration and eicosanoid metabolism","volume":"143","author":"Schreiner GF","year":"1989","journal-title":"J Immunol"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3150"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.09.053"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI67484"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep25298"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-236224"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302944"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep09750"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12466"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199911)29:11<3485::AID-IMMU3485>3.0.CO;2-B"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20130062"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2017.06.008"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2016.00003"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1159\/000131410"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfn243"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kft084"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02652.x"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2012.02.003"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2009.07.012"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114515001452"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12339"},{"issue":"4","key":"e_1_2_9_51_1","first-page":"5","article-title":"Review of evidence for dietary influences on atopic dermatitis","volume":"19","author":"Mohajeri S","year":"2014","journal-title":"Skin Therapy Lett"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.22456\/1679-9216.79403"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2008.08052"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-1557"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16561-5"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.108.101170"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5913.247"},{"issue":"9","key":"e_1_2_9_58_1","first-page":"113","article-title":"Evaluation of the anti\u2010inflammatory activities of 5,8,11\u2010 cis \u2010eicosatrienoic acid","volume":"4","author":"Hsu L\u2010C","year":"2013","journal-title":"Food Nutr Sci"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28034"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200202114"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.4161\/sgtp.29469"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.supplement_1.ltta-18"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.6.2261"},{"issue":"19","key":"e_1_2_9_64_1","doi-asserted-by":"crossref","first-page":"11784","DOI":"10.1016\/S0021-9258(20)71280-9","article-title":"Leukotriene B formation by neutrophils from essential fatty acid\u2010deficient rats","volume":"259","author":"Stenson WF","year":"1984","journal-title":"J Biol Chem"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1MR0915-403"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2016.04.002"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002336"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2828(95)90491-3"},{"issue":"3","key":"e_1_2_9_69_1","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1182\/blood.V58.3.658.658","article-title":"Leukotriene B4 is a potent and stereospecific stimulator of neutrophil chemotaxis and adherence","volume":"58","author":"Palmblad J","year":"1981","journal-title":"Blood"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/jidsymp.2011.5"},{"issue":"1","key":"e_1_2_9_71_1","first-page":"3","article-title":"Arachidonic acid metabolism: role in inflammation","volume":"50","author":"Samuelsson B","year":"1991","journal-title":"Z Rheumatol"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00916243"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1981.tb11000.x"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-121277"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12520900"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63986-7"},{"key":"e_1_2_9_77_1","article-title":"Prescriptions for atopic dermatitis: oral corticosteroids remain commonplace","volume":"1","author":"Alexander T","year":"2017","journal-title":"J Dermatolog Treat"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200110000-00006"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.142483"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.10.010"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.13762","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.13762","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/all.13762","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.13762","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T19:07:24Z","timestamp":1694286444000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.13762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,10]]},"references-count":79,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1111\/all.13762"],"URL":"https:\/\/doi.org\/10.1111\/all.13762","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"type":"print","value":"0105-4538"},{"type":"electronic","value":"1398-9995"}],"subject":[],"published":{"date-parts":[[2019,4,10]]},"assertion":[{"value":"2018-06-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}