{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:29:58Z","timestamp":1790461798680,"version":"4.1.0"},"reference-count":72,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T00:00:00Z","timestamp":1554163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The genetic determinants of food allergy have not been systematically reviewed. We therefore systematically reviewed the literature on the genetic basis of food allergy, identifying areas for further investigation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched three electronic databases (MEDLINE, EMBASE and PubMed) on 9 January 2018. Two authors screened retrieved articles for review according to inclusion criteria and extracted relevant information on study characteristics and measures of association. Eligible studies included those that reported an unaffected nonatopic control group, had genetic information and were carried out in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 2088 studies retrieved, 32 met our inclusion criteria. Five were genome\u2010wide association studies, and the remaining were candidate gene studies. Twenty\u2010two of the studies were carried out in a predominantly Caucasian population with the remaining 10 from Asian\u2010specific populations or unspecified ethnicity. We found <jats:italic>FLG, HLA, IL10, IL13, <\/jats:italic>as well as some evidence for other variants (<jats:italic>SPINK5, SERPINB <\/jats:italic>and <jats:italic>C11orf30<\/jats:italic>) that are associated with food allergy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Little genetic research has been carried out in food allergy, with <jats:italic>FLG, HLA <\/jats:italic>and <jats:italic>IL13 <\/jats:italic>being the most reproducible genes for an association with food allergy. Despite promising results, existing genetic studies on food allergy are inundated with issues such as inadequate sample size and absence of multiple testing correction. Few included replication analyses or population stratification measures. Studies addressing these limitations along with functional studies are therefore needed to unravel the mechanisms of action of the identified genes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.13767","type":"journal-article","created":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T03:37:42Z","timestamp":1551843462000},"page":"1631-1648","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Genetic determinants of paediatric food allergy: A systematic review"],"prefix":"10.1111","volume":"74","author":[{"given":"Noor H. 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