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The understanding of the relationship between\n                    <jats:italic>S\u00a0aureus<\/jats:italic>\n                    virulence factors and the immune system is continuously improving. Although the precise mechanism of the host's immune response adaptation to the variable secretion profile of\n                    <jats:italic>S\u00a0aureus<\/jats:italic>\n                    strains continues to be a matter of debate, an increasing number of studies have reported on central effects of\n                    <jats:italic>S\u00a0aureus<\/jats:italic>\n                    secretome in allergy. In this review, we discuss how colonization of\n                    <jats:italic>S\u00a0aureus<\/jats:italic>\n                    modulates the innate and adaptive immune response, thereby predisposing the organism to allergic sensitization and disrupting immune tolerance in the airways of patients with asthma and chronic rhinosinusitis with nasal polyps. 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The role of the\n                    <jats:italic>S\u00a0aureus<\/jats:italic>\n                    serine protease\u2010like proteins in the initiation of a type 2 response and the contribution of the IL\u201033\/ST2 signaling axis in allergic responses induced by bacterial allergens are discussed.\n                  <\/jats:p>","DOI":"10.1111\/all.13783","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T23:51:36Z","timestamp":1553039496000},"page":"2077-2086","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Protease\/antiprotease network in allergy: The role of\n                    <i>Staphylococcus aureus<\/i>\n                    protease\u2010like proteins"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5019-0752","authenticated-orcid":false,"given":"Olga","family":"Krysko","sequence":"first","affiliation":[{"name":"Upper Airways 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