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We performed a systematic review of all relevant publications in MEDLINE, Scopus, and Web Science including systematic reviews and meta\u2010analysis. Publications were considered relevant if they addressed treatments, or management strategies of OA. A further wider systematic literature search was performed if no evidence or good quality evidence was found. There are effective drugs for the treatment of OA; however, there is a lack an optimal treatment for the perennial and severe forms. Topical antihistamines, mast cell stabilizers, or double\u2010action drugs are the first choice of treatment. All of them are effective in reducing signs and symptoms of OA. The safety and optimal dosing regimen of the most effective topical anti\u2010inflammatory drugs, corticosteroids, are still a major concern. Topical calcineurin inhibitors may be used in steroid\u2010dependent\/resistant cases of severe allergic keratoconjunctivitis. Allergen\u2010specific immunotherapy may be considered in cases of failure of first\u2010line treatments or to modify the natural course of OA disease. Based on the current wealth of publications and on the collective experience, recommendations on management of OA have been proposed.<\/jats:p>","DOI":"10.1111\/all.13786","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T01:11:56Z","timestamp":1553044316000},"page":"1611-1630","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Management of ocular allergy"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7246-8580","authenticated-orcid":false,"given":"Andrea","family":"Leonardi","sequence":"first","affiliation":[{"name":"Ophthalmology Unit, Department of Neuroscience University of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Silva","sequence":"additional","affiliation":[{"name":"Basic and Clinical Immunology, Department of Pathology, Faculty of Medicine, Servi\u00e7o de Imunoalergologia, 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