{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:06:53Z","timestamp":1790838413449,"version":"4.1.0"},"reference-count":206,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T00:00:00Z","timestamp":1571961600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Inflammation, structural, and functional abnormalities within the airways are key features of asthma. Although these processes are well documented, their expression varies across the heterogeneous spectrum of asthma. Type 2 inflammatory responses are characterized by increased levels of eosinophils, Fe<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>, and type 2 cytokines in blood and\/or airways. Presently, type 2 asthma is the best\u2010defined endotype, typically found in patients with allergic asthma, but surprisingly also in nonallergic patients with (severe) asthma. The etiology of asthma with non\u2010type 2 inflammation is less clear. During the past decade, targeted therapies, including biologicals and small molecules, have been increasingly integrated into treatment strategies of severe asthma. These treatments block specific inflammatory pathways or single mediators. Single or composite biomarkers help to identify patients who will benefit from these treatments. So far, only a few inflammatory biomarkers have been validated for clinical application. The European Academy of Allergy &amp; Clinical Immunology Task Force on Biomarkers in Asthma was initiated to review different biomarker sampling methods and to investigate clinical applicability of new and existing inflammatory biomarkers (point\u2010of\u2010care) to support diagnosis, targeted treatment, and monitoring of severe asthma. Subsequently, we discuss existing and novel targeted therapies for asthma as well as applicable biomarkers.<\/jats:p>","DOI":"10.1111\/all.13806","type":"journal-article","created":{"date-parts":[[2019,4,6]],"date-time":"2019-04-06T14:13:15Z","timestamp":1554559995000},"page":"1835-1851","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":193,"title":["Toward clinically applicable biomarkers for asthma: An <scp>EAACI<\/scp> position paper"],"prefix":"10.1111","volume":"74","author":[{"given":"Zuzana","family":"Diamant","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine and Allergology Institute for Clinical Science Skane University Hospital Lund Sweden"},{"name":"Department of Clinical Pharmacy and Pharmacology UMCG and QPS\u2010NL Groningen The Netherlands"},{"name":"Department of Respiratory Medicine First Faculty of Medicine Charles University and Thomayer Hospital Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4579-4081","authenticated-orcid":false,"given":"Susanne","family":"Vijverberg","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Amsterdam UMC University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjell","family":"Alving","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arzu","family":"Bakirtas","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Allergy and Asthma Gazi University School of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif","family":"Bjermer","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Pharmacology UMCG and QPS\u2010NL Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Custovic","sequence":"additional","affiliation":[{"name":"Section of Paediatrics Department of Medicine Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven\u2010Erik","family":"Dahlen","sequence":"additional","affiliation":[{"name":"Experimental Asthma and Allergy Research Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Gaga","sequence":"additional","affiliation":[{"name":"7th Respiratory Medicine Department and Asthma Centre Athens Chest Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Gerth van Wijk","sequence":"additional","affiliation":[{"name":"Section of Allergology Department of Internal Medicine Erasmus Medical Center Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Del Giacco","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences and Public Health University of Cagliari Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2996-8248","authenticated-orcid":false,"given":"Eckard","family":"Hamelmann","sequence":"additional","affiliation":[{"name":"Children's Center Protestant Hospital Bethel Bielefeld Germany"},{"name":"Allergy Center Ruhr University Bochum Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam G.","family":"Heaney","sequence":"additional","affiliation":[{"name":"Centre for Experimental Medicine, School of Medicine Dentistry and Biomedical Sciences, Queen's University Belfast Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0492-5663","authenticated-orcid":false,"given":"Enrico","family":"Heffler","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University Milan Italy"},{"name":"Personalized Medicine, Asthma and Allergy Humanitas Research Hospital Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6mer","family":"Kalayci","sequence":"additional","affiliation":[{"name":"Division of Pediatric Allergy Faculty of Medicine Hacettepe University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Kostikas","sequence":"additional","affiliation":[{"name":"Respiratory Medicine Department University of Ioannina Medical School Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene","family":"Lutter","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Amsterdam UMC University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna\u2010Carin","family":"Olin","sequence":"additional","affiliation":[{"name":"Section of Occupational and Environmental Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Sergejeva","sequence":"additional","affiliation":[{"name":"Institute of Technology University of Tartu Tartu Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Simpson","sequence":"additional","affiliation":[{"name":"Division of Infection, Immunity and Respiratory Medicine Faculty of Biology, Medicine and Health Manchester Academic Health Sciences Centre University of Manchester and University Hospital of South Manchester NHS Foundation Trust Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Sterk","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Amsterdam UMC University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Tufvesson","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Pharmacology UMCG and QPS\u2010NL Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7994-364X","authenticated-orcid":false,"given":"Ioana","family":"Agache","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology Faculty of Medicine Transylvania University Brasov Brasov Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4399-9892","authenticated-orcid":false,"given":"Sven F.","family":"Seys","sequence":"additional","affiliation":[{"name":"Allergy and Clinical Immunology Research Group Department of Microbiology, Immunology and Transplantation KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3049"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)33311-1"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.10.875"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200906-0896OC"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200711-1754OC"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3786"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00202013"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.11.042"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02135-2016"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-017-0524-y"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000426"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02832.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.03.010"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.09.012"},{"key":"e_1_2_11_16_1","unstructured":"FDA CDER Biomarker Qualification Program [Internet]"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02298-2016"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.06.037"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000010"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000345"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3402\/ecrj.v3.31324"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-205634"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.09.034"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12906"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(15)00050-8"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12101"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2012.713428"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/crj.12001"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23785"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01328.x"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200905-0695OC"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.08.004"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac802055k"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpf.12323"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23976"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.11.011"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.11.009"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12125"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.07.036"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200903-0392OC"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-7022-3-24"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3300"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2018.04.003"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13340"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12828"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.073429"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752-699X.2009.00162.x"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.135574"},{"key":"e_1_2_11_49_1","unstructured":"2018 GINA Report Global Strategy for Asthma Management and Prevention [Internet].2018.www.ginasthma.org. Accessed October 1 2018."},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00201813"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00034514"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(15)00419-1"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.09.028"},{"key":"e_1_2_11_54_1","article-title":"Rapid quantification of sputum eosinophil peroxidase on a lateral flow test strip","author":"Wolfe MG","year":"2018","journal-title":"Allergy"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aab3142"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0180778"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.08.027"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.9120-11ST"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2014.02.005"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986711795328436"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2010.02.006"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2018-211540"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60971-9"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01817-2017"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201411-2010LE"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12965"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12147"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.06.025"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-016-0230-4"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1106469"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-206719"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40521-016-0106-0"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(15)00197-6"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(95)70151-6"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13599"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.11.004"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-016-0208-2"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13117"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12451"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-017-2384-7"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201407-1290LE"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-13-11"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2006.00784.x"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.10.011"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-13-58"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02855.x"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201311-2011LE"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.12.963"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200707-1134OC"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00170110"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.01.059"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.09.022"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13439"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.26.6.4757"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/840315"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.12.1091"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00105013"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.02.045"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050580"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2014.8"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2010.02.018"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2006.02502.x"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13043"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00029705"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13184"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00053506"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201110-1849OC"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.6.2001041"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200205-414OC"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200602-189OC"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90067-6"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200209-1030OC"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.R-07-153"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.4.309"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.4.9806052"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI17974"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00111806"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)70050-2"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03447.x"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13601-017-0143-1"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2014.08.010"},{"issue":"1","key":"e_1_2_11_122_1","first-page":"385","article-title":"Galectin\u20103 down\u2010regulates IL\u20105 gene expression on different cell types","volume":"161","author":"Cortegano I","year":"1998","journal-title":"J Immunol Baltim Md 1950"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-012110-142250"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.03.003"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12452"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201210-1886OC"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2008.10.006"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.1.58"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2007.02746.x"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.02334.x"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2003.11.026"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2016.37.3945"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin16.215"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-12-85"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000375"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12616"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13138"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.supplement_1.2103026"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.4137\/CCRPM.S7793"},{"issue":"1","key":"e_1_2_11_140_1","first-page":"CD003559","article-title":"Omalizumab for asthma in adults and children","author":"Normansell R","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2018.04.043"},{"key":"e_1_2_11_142_1","first-page":"CD012393","article-title":"Interventions for autumn exacerbations of asthma in children","volume":"3","author":"Pike KC","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02119.x"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2012.07.010"},{"key":"e_1_2_11_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2014.03.010"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.225"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201208-1414OC"},{"key":"e_1_2_11_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.09.008"},{"key":"e_1_2_11_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.12.1317"},{"key":"e_1_2_11_150_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0805435"},{"key":"e_1_2_11_151_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808991"},{"key":"e_1_2_11_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.05.020"},{"key":"e_1_2_11_153_1","first-page":"CD010834","article-title":"Anti\u2010IL5 therapies for asthma","volume":"9","author":"Farne HA","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03496-6"},{"key":"e_1_2_11_155_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200701-085OC"},{"key":"e_1_2_11_156_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1403291"},{"key":"e_1_2_11_157_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1403290"},{"key":"e_1_2_11_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(15)00042-9"},{"key":"e_1_2_11_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60988-X"},{"key":"e_1_2_11_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.03.030"},{"key":"e_1_2_11_161_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1804092"},{"key":"e_1_2_11_162_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1304048"},{"key":"e_1_2_11_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30307-5"},{"key":"e_1_2_11_164_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.19330"},{"key":"e_1_2_11_165_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1804093"},{"key":"e_1_2_11_166_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707413104"},{"key":"e_1_2_11_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(16)30265-X"},{"key":"e_1_2_11_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.04.050"},{"key":"e_1_2_11_169_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1211622"},{"key":"e_1_2_11_170_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.11-RAI-0376"},{"issue":"12","key":"e_1_2_11_171_1","first-page":"8183","article-title":"Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2\u2010attracting chemokines and disease severity","volume":"174","author":"Ying S","year":"2005","journal-title":"J Immunol Baltim Md 1950"},{"key":"e_1_2_11_172_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402895"},{"key":"e_1_2_11_173_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1704064"},{"key":"e_1_2_11_174_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.2.255"},{"key":"e_1_2_11_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.10.056"},{"key":"e_1_2_11_176_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00092111"},{"key":"e_1_2_11_177_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12357"},{"key":"e_1_2_11_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.01.035"},{"key":"e_1_2_11_179_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S105142"},{"key":"e_1_2_11_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2015.03.003"},{"key":"e_1_2_11_181_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00670-2017"},{"key":"e_1_2_11_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(16)30179-5"},{"key":"e_1_2_11_183_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000544"},{"key":"e_1_2_11_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(95)00463-U"},{"key":"e_1_2_11_185_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.045260"},{"key":"e_1_2_11_186_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200809-1512OC"},{"key":"e_1_2_11_187_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201212-2318OC"},{"key":"e_1_2_11_188_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00186109"},{"key":"e_1_2_11_189_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2012.04014.x"},{"key":"e_1_2_11_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(16)30227-2"},{"key":"e_1_2_11_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2007.11.001"},{"key":"e_1_2_11_192_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-202698"},{"key":"e_1_2_11_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31281-3"},{"key":"e_1_2_11_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(16)30018-2"},{"key":"e_1_2_11_195_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-017-0554-8"},{"key":"e_1_2_11_196_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa064707"},{"key":"e_1_2_11_197_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200704-571OC"},{"key":"e_1_2_11_198_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200903-0354OC"},{"key":"e_1_2_11_199_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00017-2017"},{"key":"e_1_2_11_200_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00158"},{"key":"e_1_2_11_201_1","unstructured":"NIH\u2010National Cancer Institute [Internet].https:\/\/www.cancer.gov\/publications\/dictionaries\/genetics-dictionary\/def\/phenotype. Accessed October 1 2018."},{"key":"e_1_2_11_202_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61452-X"},{"key":"e_1_2_11_203_1","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2001.113989"},{"key":"e_1_2_11_204_1","first-page":"CD011440","article-title":"Exhaled nitric oxide levels to guide treatment for adults with asthma","volume":"9","author":"Petsky HL","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_205_1","doi-asserted-by":"crossref","first-page":"9s","DOI":"10.1183\/09031936.02.00000902","article-title":"Safety of sputum induction","volume":"37","author":"Pizzichini E","year":"2002","journal-title":"Eur Respir J Suppl"},{"key":"e_1_2_11_206_1","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2018.1457440"},{"key":"e_1_2_11_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2010.10.015"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.13806","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/all.13806","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.13806","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T00:03:57Z","timestamp":1693958637000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.13806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":206,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1111\/all.13806"],"URL":"https:\/\/doi.org\/10.1111\/all.13806","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"2019-03-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}