{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T20:08:52Z","timestamp":1788206932596,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T00:00:00Z","timestamp":1562544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000354","name":"Food Standards Agency","doi-asserted-by":"publisher","award":["T07051"],"award-info":[{"award-number":["T07051"]}],"id":[{"id":"10.13039\/501100000354","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_G1001205"],"award-info":[{"award-number":["MC_G1001205"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["NIHRCS\/01\/2008\/009"],"award-info":[{"award-number":["NIHRCS\/01\/2008\/009"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["092530\/Z\/10\/Z"],"award-info":[{"award-number":["092530\/Z\/10\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The prevention of food allergy is a key priority for reducing the burden of allergic disease. Environmental exposures modulate the risk of developing food allergy and some of this may be mediated by the infants\u2019 developing microbiome. However, the role of potentially protective environmental exposures, such as pet ownership, is largely uninvestigated with respect to food allergy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a secondary cohort analysis in the Enquiring About Tolerance (EAT) study, which enrolled 1303 three\u2010month infants onto a randomized trial to prevent food allergy. A survey elicited domestic animal ownership and participants were examined for atopic dermatitis (AD) at enrolment. Sensitization to foods and aeroallergens were elicited by skin and serum testing at 3, 12 and 36\u00a0months. Food allergy status was determined by double\u2010blind placebo\u2010controlled food challenges between 1 and 3\u00a0years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Food allergy was diagnosed amongst 6.1% (68\/1124) of participants with complete data. No significant relationships were demonstrated between food allergy and caesarean delivery, infections or antibiotic exposure in early life. After adjusting for familial atopic disease, maternal dog\/cat sensitization and participant AD, living with dogs was associated with a 90% reduction in the odds of infants developing food allergy (adjusted odds ratio (aOR) 0.10 (confidence interval (CI) 0.01\u20100.71),\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.02). None of the 49 infants living with at least two dogs developed food allergy, suggesting a dose\u2010response relationship (each dog owned aOR 0.12 (CI 0.02\u20100.81),\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.03). No relationship was demonstrated between owning dogs or cats and the development of AD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Dog ownership in infancy may prevent food allergy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.13868","type":"journal-article","created":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T13:05:21Z","timestamp":1557579921000},"page":"2212-2219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Dog ownership at three months of age is associated with protection against food allergy"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2865-0606","authenticated-orcid":false,"given":"Tom","family":"Marrs","sequence":"first","affiliation":[{"name":"Paediatric Allergy Department, Women and Children\u2019s Health King\u2019s College London London UK"},{"name":"Children\u2019s Allergies Department, Evelina London, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust St Thomas\u2019 Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsty","family":"Logan","sequence":"additional","affiliation":[{"name":"Paediatric Allergy Department, Women and Children\u2019s Health King\u2019s College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Craven","sequence":"additional","affiliation":[{"name":"Paediatric Allergy Department, Women and Children\u2019s Health King\u2019s College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzana","family":"Radulovic","sequence":"additional","affiliation":[{"name":"Paediatric Allergy Department, Women and Children\u2019s Health King\u2019s College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.H.A. Irwin","family":"McLean","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine, Centre for Dermatology and Genetic Medicine University of Dundee Dundee UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7350-4021","authenticated-orcid":false,"given":"Gideon","family":"Lack","sequence":"additional","affiliation":[{"name":"Paediatric Allergy Department, Women and Children\u2019s Health King\u2019s College London London UK"},{"name":"Children\u2019s Allergies Department, Evelina London, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust St Thomas\u2019 Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Flohr","sequence":"additional","affiliation":[{"name":"Unit for Population\u2010Based Dermatology Research, St John\u2019s Institute of Dermatology King\u2019s College London and Guy\u2019s &amp; St Thomas\u2019 Hospital NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Perkin","sequence":"additional","affiliation":[{"name":"Population Health Research Institute, St George\u2019s University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the EAT Study Team","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1514210"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.01.039"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12476"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.02939.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1508749"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09641-1"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.12.1301"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12349"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.10.030"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)05406-X"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.02.017"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.09.030"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.12.1570"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043214"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127756"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12064"},{"key":"e_1_2_8_18_1","volume-title":"Agricultural labour in the UK","author":"Devlin S"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2011.01254.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-6148-3-5"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12015"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13601-016-0089-8"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1334"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.12.1322"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.117978"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2009.00376.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10068.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng2020"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.01.038"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.09.015"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2015.1099161"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.10.010"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.01.037"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.03.041"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1596"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.08.026"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2015.1139"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2015.02.003"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1205624109"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.06.024"}],"updated-by":[{"DOI":"10.1111\/all.14249","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000}}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.13868","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.13868","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/all.13868","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.13868","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:06:12Z","timestamp":1693526772000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.13868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,8]]},"references-count":39,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1111\/all.13868"],"URL":"https:\/\/doi.org\/10.1111\/all.13868","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,8]]},"assertion":[{"value":"2018-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}