{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:45:44Z","timestamp":1790624744004,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T00:00:00Z","timestamp":1559433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Scabies is a common contagious skin disease caused by an infestation of the skin by\n                      <jats:italic>Sarcoptes scabiei<\/jats:italic>\n                      var.\n                      <jats:italic>hominis<\/jats:italic>\n                      . A hallmark symptom of scabies is severe itch.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We sought to determine the generation of a pruritogenic cytokine, interleukin (IL)\u201031, together with immune profiles in skin lesions of ordinary scabies through immunohistochemical and immunofluorescent studies. To elucidate the pathological mechanisms of IL\u201031 generation, murine peritoneal macrophages were stimulated with various T helper 2 (Th2) cytokines and proteins ex vivo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A large number of CCR4(+) Th2 cells, eosinophils, and basophils infiltrated in scabies lesions. Increased generation of IL\u201031, thymic stromal lymphopoietin (TSLP), and periostin was also observed. A major population of IL\u201031(+) cells were Arginase\u20101(+)\/CD163(+) M2 macrophages. Murine peritoneal macrophages showed an M2 phenotype and generated IL\u201031 when stimulated with TSLP and periostin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IL\u201031 appeared to be largely generated by M2 macrophages in ordinary scabies lesions. This IL\u201031 induction was mediated by TSLP and periostin.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.13870","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T12:30:15Z","timestamp":1557837015000},"page":"1727-1737","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Pruritus in ordinary scabies: IL\u201031 from macrophages induced by overexpression of thymic stromal lymphopoietin and periostin"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6779-5598","authenticated-orcid":false,"given":"Takashi","family":"Hashimoto","sequence":"first","affiliation":[{"name":"Department of Dermatology, Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan"},{"name":"Department of Dermatology National Defense Medical College Saitama 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