{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T19:06:23Z","timestamp":1785524783363,"version":"3.56.0"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T00:00:00Z","timestamp":1563926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008723","name":"Suomen L\u00e4\u00e4ketieteen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004012","name":"Jane ja Aatos Erkon S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004012","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006706","name":"Tampereen Tuberkuloosis\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006706","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007417","name":"Paulon S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007417","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim was to study the association between allergic multimorbidity and adult\u2010onset asthma considering the number of allergic diseases and the age effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used population\u2010based data from Finnish national registers including 1205 adults over 30\u00a0years of age with recently diagnosed asthma (age range: 30\u201093), matched for gender, age, and living region with one or two controls (n\u00a0=\u00a02050). Allergic rhinitis (AR), allergic conjunctivitis (AC), and allergic dermatitis (AD) were defined from self\u2010completed questionnaire. Conditional logistic regression adjusted on potential confounders (smoking, growing in countryside, childhood hospitalized infection\/pneumonia, parental asthma\/allergy, parental smoking, education level, professional training, number of siblings, and birth order) was applied to estimate the asthma risk associated with allergic multimorbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1118 cases with asthma and 1772 matched controls were included [mean (<jats:italic>SD<\/jats:italic>, min\u2010max) 53 (11, 31\u201071) years, 37% men)]. AR, AC, and AD were reported by 50.2%, 39.6%, and 33.8%, respectively, among subjects with asthma and 26.1%, 20.0%, and 23.5%, respectively, among controls. Compared to nonatopics, adult\u2010onset asthma increased with the number of allergic diseases; adjusted OR for asthma [95% CI] associated with 1, 2, and 3 allergic diseases was 1.95 [1.52\u20102.49], 2.87 [2.19\u20103.77], and 4.26 [3.07\u20105.90], respectively. The association between adult\u2010onset asthma and\u00a0\u2265\u00a01 allergic multimorbidity decreased with increasing age (3.52 [2.51\u20104.94], 2.44 [1.74\u20103.42], and 1.68 [1.04\u20102.71]) in subjects\u00a0&lt;\u00a050\u00a0years, 50\u201062\u00a0years, and\u00a0&gt;\u00a062\u00a0years, respectively (p for age*\u22651 allergic multimorbidity interaction, 0.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adult\u2010onset asthma was positively associated with the number of allergic diseases, and this association decreases with age.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.13971","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T19:50:15Z","timestamp":1562183415000},"page":"2406-2416","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Risk of adult\u2010onset asthma increases with the number of allergic multimorbidities and decreases with age"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0890-6686","authenticated-orcid":false,"given":"Sanna","family":"Toppila\u2010Salmi","sequence":"first","affiliation":[{"name":"Haartman Institute, Medicum University of Helsinki Helsinki Finland"},{"name":"Skin and Allergy Hospital Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Chanoine","sequence":"additional","affiliation":[{"name":"Institute for Advanced Biosciences UGA \/ Inserm U 1209 \/ CNRS UMR 5309 Joint Research Center Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health La Tronche France"},{"name":"P\u00f4le Pharmacie CHU Grenoble Alpes Grenoble France"},{"name":"Universit\u00e9 Grenoble Alpes Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jussi","family":"Karjalainen","sequence":"additional","affiliation":[{"name":"Allergy Centre Tampere University Hospital Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"Pekkanen","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Helsinki Helsinki Finland"},{"name":"Environmental Health National Institute for Health and Welfare Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Bousquet","sequence":"additional","affiliation":[{"name":"Fondation FMC VIA\u2010LR &amp; MACVIA\u2010France Montpellier France"},{"name":"INSERM U 1168 VIMA: Ageing and chronic Diseases Epidemiological and Public Health Approaches Villejuif France"},{"name":"UMR\u2010S 1168 Universit\u00e9 Versailles St\u2010Quentin\u2010en\u2010Yvelines Montigny le Bretonneux France"},{"name":"Euforea Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7329-7237","authenticated-orcid":false,"given":"Val\u00e9rie","family":"Siroux","sequence":"additional","affiliation":[{"name":"Institute for Advanced Biosciences UGA \/ Inserm U 1209 \/ CNRS UMR 5309 Joint Research Center Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health La Tronche 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