{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:36:49Z","timestamp":1787168209604,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T00:00:00Z","timestamp":1571788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic rhinosinusitis with nasal polyposis (CRSwNP) negatively affects health\u2010related quality of life (HRQoL). In a previously reported randomized clinical trial (NCT01920893), addition of dupilumab to mometasone furoate in patients with CRSwNP refractory to intranasal corticosteroids (INCS) significantly improved endoscopic, radiographic, and clinical endpoints and patient\u2010reported outcomes. The objective of this analysis was to examine the impact of dupilumab treatment on HRQoL and productivity using secondary outcome data from this trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Following a 4\u2010week mometasone furoate nasal spray run\u2010in, patients were randomized to commence subcutaneous dupilumab (600\u00a0mg loading dose, then 300\u00a0mg once weekly for 15\u00a0weeks [n\u00a0=\u00a030], or matched placebo [n\u00a0=\u00a030]). Outcomes included scores on the CRS disease severity visual analog scale (VAS), 22\u2010item Sino\u2010Nasal Outcome Test (SNOT\u201022), 5\u2010dimension EuroQoL (EQ\u20105D) general health status VAS, and 36\u2010item Short\u2010Form Health Survey (SF\u201036) for HRQoL and nasal polyp\u2010related healthcare resource use questionnaires.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Following 16\u00a0weeks of treatment, the proportion of patients with moderate\u2010to\u2010severe CRSwNP (VAS\u00a0&gt;\u00a03\u201010) decreased from 86.2% to 21.4% with dupilumab and 88.0% to 84.2% with placebo. Dupilumab (vs placebo) resulted in significantly greater improvement in HRQoL, based on SNOT\u201022, SF\u201036, and EQ\u20105D VAS scores. The dupilumab group had a significantly lower adjusted annualized mean number of sick leave days (0.09, vs 4.18 with placebo,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.015) and significantly greater improvement (vs placebo) in the SNOT\u201022 item \u201creduced productivity.\u201d\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In adults with CRSwNP refractory to treatment with INCS alone, the addition of dupilumab reduced disease severity, significantly improved HRQoL, and improved productivity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.13984","type":"journal-article","created":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T16:10:27Z","timestamp":1563207027000},"page":"148-157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["Dupilumab improves health\u2010related quality of life in patients with chronic rhinosinusitis with nasal polyposis"],"prefix":"10.1111","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4742-1665","authenticated-orcid":false,"given":"Claus","family":"Bachert","sequence":"first","affiliation":[{"name":"Ghent University Hospital Ghent Belgium"},{"name":"CLINTEC, Karolinska Institute Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter W.","family":"Hellings","sequence":"additional","affiliation":[{"name":"University Hospitals Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquim","family":"Mullol","sequence":"additional","affiliation":[{"name":"IDIBAPS (Hospital Cl\u00ednic de Barcelona, University of Barcelona, and CIBERES) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L.","family":"Hamilos","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Gevaert","sequence":"additional","affiliation":[{"name":"Ghent University Hospital Ghent Belgium"},{"name":"CLINTEC, Karolinska Institute Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Naclerio","sequence":"additional","affiliation":[{"name":"Johns Hopkins Hospital Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay N.","family":"Joish","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals, Inc. 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