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CRS is being increasingly recognized as a disease spectrum encompassing a range of inflammatory states in the sinonasal cavity, with non\u2010type 2 inflammatory disease on one end, type 2 inflammatory, eosinophil\u2010heavy disease on the other and an overlap of both in different proportions in between. Abundance in research on the immune mechanisms of CRS has revealed various new endotypes that hold promise as biomarkers for the development of targeted therapies in severe, uncontrolled CRS. The introduction of precision medicine to manage this chronic, complex condition is a step forward in providing individualized care for all patients with CRS. In this review, the latest research on the pathophysiology of CRS with a focus on potential novel biomarkers and treatment options over the last 2\u00a0years are summarized and integrated into a suggested model of precision medicine in CRS.<\/jats:p>","DOI":"10.1111\/all.14044","type":"journal-article","created":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T02:24:31Z","timestamp":1568255071000},"page":"769-780","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Novel findings in immunopathophysiology of chronic rhinosinusitis and their role in a model of precision medicine"],"prefix":"10.1111","volume":"75","author":[{"given":"Xinni","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery National University Hospital System (NUHS) Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yew 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