{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:10:45Z","timestamp":1790507445859,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T00:00:00Z","timestamp":1571788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Only a limited number of studies have included objective measures of allergic sensitisation (such as skin\u2010prick test [SPT] and serum specific IgE [sIgE]) when studying time trends in allergic respiratory disease in adults within the current millennium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Five health examination studies of random samples of individuals aged 18\u201069\u00a0years resident in the Copenhagen region were conducted in 1990\u20101991, 2006\u20102008, 2010\u20102011, 2012\u20102015, and 2016\u20102017. Allergic sensitisation was defined by sIgE (in 1990\u20101991, 2006\u20102008, and, 2012\u20102015) or SPT (in 2006\u20102008, 2010\u20102011, and 2016\u20102017) to at least one of the allergens: birch, grass, house dust mite, or cat. Allergic rhinitis was defined as sensitisation and self\u2010reported nasal symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The age\u2010 and sex\u2010standardised prevalence of sIgE\u2010defined sensitisation increased from 16% in 1990\u20101991, to 26% in 2006\u20102008, and to 29% in 2012\u20102015. The age\u2010 and sex\u2010standardised prevalence of SPT\u2010defined sensitisation increased from 27% in 2006\u20102008, to 28% in 2010\u20102011, and to 32% in 2016\u20102017. Changes in sIgE\u2010defined and SPT\u2010defined allergic rhinitis showed similar increasing trends.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The prevalence of allergic sensitisation and allergic rhinitis increased in a general adult Danish population over the last three decades and has thus continued to increase in the current millennium.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.14046","type":"journal-article","created":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T22:23:40Z","timestamp":1568240620000},"page":"660-668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Allergic rhinitis and allergic sensitisation are still increasing among Danish 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Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0994-0184","authenticated-orcid":false,"given":"Allan","family":"Linneberg","sequence":"additional","affiliation":[{"name":"Center for Clinical Research and Prevention Bispebjerg and Frederiksberg Hospital Frederiksberg Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen 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