{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:06:10Z","timestamp":1780056370952,"version":"3.54.0"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T00:00:00Z","timestamp":1572480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      It is suggested that airway fungi, in particular\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      may impinge on clinical phenotype in asthma. Indeed, the term severe asthma with fungal sensitization (SAFS) has been coined. We aimed to ascertain whether the presence of fungi, in particular\n                      <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                      , in the airway correlated with asthma severity and control. Furthermore, we aimed to determine whether traditional markers of\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      sensitization related to the presence of\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      within the airway.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010nine patients characterized by asthma severity (GINA) and level of control (ACQ\u20107) underwent bronchoscopy and bronchoalveolar lavage (BAL). Serum was assessed for\n                      <jats:italic>A\u00a0fumigatus\u2010<\/jats:italic>\n                      specific IgE and total IgE. Galactomannan and relevant cytokine levels were assessed in serum, plasma and BAL. BAL was analyzed for the presence of\n                      <jats:italic>A\u00a0fumigatus.<\/jats:italic>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In BAL, fungi were visible by microscopy in 70% and present by qPCR in 86% of patients, while\n                      <jats:italic>A\u00a0fumigatus<\/jats:italic>\n                      was detectable by qPCR in 46%. Plasma and BAL IL\u20104, IL\u20106, IL\u201010, IL\u201013 and TNF\u2010\u03b1 correlated with BAL fungal presence, while plasma IL\u201017 correlated with BAL fungal presence.\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      positive BAL correlated with increased plasma and BAL IL\u20106 and BAL IL\u201013. There was no relationship between fungal airway presence and steroid dose, asthma severity or control. The presence of\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      within the airway did not relate to serum IgE positivity for\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Fungi were present in a large proportion of our asthmatic patients\u2019 airways, but their presence was not predicted by traditional markers of sensitization, nor did it appear to be related to measures of disease severity or control.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.14087","type":"journal-article","created":{"date-parts":[[2019,10,12]],"date-time":"2019-10-12T15:49:00Z","timestamp":1570895340000},"page":"1146-1154","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The presence of\n                    <i>Aspergillus fumigatus<\/i>\n                    in asthmatic airways is not clearly related to clinical disease severity"],"prefix":"10.1111","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7718-9305","authenticated-orcid":false,"given":"Ashley","family":"Sullivan","sequence":"first","affiliation":[{"name":"The APC Microbiome Ireland University College Cork Cork Ireland"},{"name":"The Schools of Medicine and Microbiology University College Cork Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eoin B.","family":"Hunt","sequence":"additional","affiliation":[{"name":"The Department of Respiratory 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