{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:29:07Z","timestamp":1791584947039,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T00:00:00Z","timestamp":1575244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19AI106683"],"award-info":[{"award-number":["U19AI106683"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic rhinosinusitis (CRS) epidemiology has been largely studied using symptom\u2010based case definitions, without assessment of objective sinus findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe radiologic sinus opacification and the prevalence of CRS, defined by the co\u2010occurrence of symptoms and sinus opacification, in a general population\u2010based sample.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We collected questionnaires and sinus CT scans from 646 participants selected from a source population of 200\u00a0769 primary care patients. Symptom status (CRS\n                      <jats:sub>S<\/jats:sub>\n                      ) was based on guideline criteria, and objective radiologic inflammation (CRS\n                      <jats:sub>O<\/jats:sub>\n                      ) was based on the Lund\u2010Mackay (L\u2010M) score using multiple L\u2010M thresholds for positivity. Participants with symptoms and radiologic inflammation were classified as CRS\n                      <jats:sub>S+O<\/jats:sub>\n                      . We performed negative binomial regression to assess factors associated with L\u2010M score and logistic regression to evaluate factors associated with CRS\n                      <jats:sub>S+O<\/jats:sub>\n                      . Using weighted analysis, we calculated estimates for the source population.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The proportion of women with L\u2010M scores\u00a0\u2265\u00a03, 4, or 6 (CRS\n                      <jats:sub>O<\/jats:sub>\n                      ) was 11.1%, 9.9%, and 5.7%, respectively, and 16.1%, 14.6%, and 8.7% among men. The respective proportion with CRS\n                      <jats:sub>S+O<\/jats:sub>\n                      was 1.7%, 1.6%, and 0.45% among women and 8.8%, 7.5%, and 3.6% among men. Men had higher odds of CRS\n                      <jats:sub>S+O<\/jats:sub>\n                      compared to women. A greater proportion of men (vs women) had any opacification in the frontal, anterior ethmoid, and sphenoid sinuses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In a general population\u2010based sample in Pennsylvania, sinus opacification was more common among men than in women and opacification occurred in different locations by sex. Male sex, migraine headache, and prior sinus surgery were associated with higher odds of CRS\n                      <jats:sub>S+O<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.14106","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T01:08:44Z","timestamp":1573520924000},"page":"911-920","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Radiologic sinus inflammation and symptoms of chronic rhinosinusitis in a population\u2010based sample"],"prefix":"10.1111","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7699-2171","authenticated-orcid":false,"given":"Annemarie G.","family":"Hirsch","sequence":"first","affiliation":[{"name":"Department of Population Health Sciences Geisinger Danville Pennsylvania"},{"name":"Department of Environmental Health and Engineering Johns Hopkins University Bloomberg School of Public Health Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cara","family":"Nordberg","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Translational Informatics Geisinger Danville Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Bandeen\u2010Roche","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Johns Hopkins School of Public Health Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce K.","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Northwestern University Feinberg School of Medicine Chicago Illinois"},{"name":"Division of Allergy and Immunology Department of Medicine Northwestern University Feinberg School of Medicine Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Schleimer","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Northwestern University Feinberg School of Medicine Chicago Illinois"},{"name":"Division of Allergy and Immunology Department of Medicine Northwestern University Feinberg School of Medicine Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Kern","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Northwestern University Feinberg School of Medicine Chicago Illinois"},{"name":"Division of Allergy and Immunology Department of Medicine Northwestern University Feinberg School of Medicine Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Sundaresan","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences Geisinger Danville Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayant M.","family":"Pinto","sequence":"additional","affiliation":[{"name":"Section of Otolaryngology\u2010Head and Neck Surgery Department of Surgery The University of Chicago Medicine Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas L.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck\/Facial Plastic Surgery Geisinger Danville Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph Scott","family":"Greene","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck\/Facial Plastic Surgery Geisinger Danville Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan R.","family":"Kuiper","sequence":"additional","affiliation":[{"name":"Department of Environmental Health and Engineering Johns Hopkins University Bloomberg School of Public Health Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0739-9865","authenticated-orcid":false,"given":"Brian S.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences Geisinger Danville Pennsylvania"},{"name":"Department of Environmental Health and Engineering Johns Hopkins University Bloomberg School of Public Health Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201308-1500ED"},{"key":"e_1_2_9_3_1","first-page":"3","article-title":"European position paper on rhinosinusitis and nasal polyps 2012","volume":"23","author":"Fokkens WJ","year":"2012","journal-title":"Rhinol Suppl"},{"issue":"1","key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1002\/alr.21695","article-title":"International consensus statement on allergy and rhinology: rhinosinusitis","volume":"6","author":"Orlandi RR","year":"2016","journal-title":"Int Forum Allergy Rhinol"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.02.004"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1988.01860200040012"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989770005-6"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.4936.395"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.119324"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.12.986"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13042"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healthplace.2013.03.012"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000078940.53438.83"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.10.012"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-7967(03)00074-3"},{"key":"e_1_2_9_16_1","unstructured":"ChowdhuryS KhareM WolterK.Weight trimming in the national immunization survey. Proceedings of the Joint Statistical Meetings Section on Survey Research Methods American Statistical Association 2007 Jul 29;26512658:2651\u20132658."},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009297"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.125.9.994"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200301000-00023"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2015.3142"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02646.x"},{"issue":"242","key":"e_1_2_9_22_1","first-page":"1","article-title":"Summary health statistics for U.S. adults: National Health Interview Survey, 2008","author":"Pleis JR","year":"2009","journal-title":"Vital Health Stat 10"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200307000-00016"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.9_suppl_6.S10"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.2500\/ar.2015.6.0120"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21082"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.05.004"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.02.036"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13470"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21446"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.08.004"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21063"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.14106","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.14106","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/all.14106","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.14106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T06:11:57Z","timestamp":1694067117000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.14106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,2]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1111\/all.14106"],"URL":"https:\/\/doi.org\/10.1111\/all.14106","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,2]]},"assertion":[{"value":"2019-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}