{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T02:15:47Z","timestamp":1787451347413,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T00:00:00Z","timestamp":1579219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001778","name":"Deakin University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001778","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A few studies have investigated the antecedents and outcomes of infants who demonstrate IgE sensitization to foods that they clinically tolerate. Improved understanding of this sensitized\u2010tolerant phenotype may inform strategies for the prevention of food allergy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In an Australian birth cohort (n\u00a0=\u00a01074), assembled using an unselected antenatal sampling frame, participants were categorized as nonsensitized (NS), sensitizedtolerant (ST), or food allergic (FA) based on skin prick testing and food challenge at 12\u00a0months of age. Environmental exposures were recorded throughout. Cord blood regulatory T\u2010cell populations were measured at birth. Subsequent childhood allergic disease was assessed by parent report, clinical examination, and repeat skin prick testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The covariates of interest varied between NS (n\u00a0=\u00a0698), ST (n\u00a0=\u00a027), and FA (n\u00a0=\u00a061) groups as follows, suggesting that across these measures, the ST group was more similar to the NS than the FA group: family history of eczema NS 44.6%, ST. 44.6%, FA 65.6%; pet ownership at 12\u00a0months: NS 71.5%, ST 81.5%, FA 45.8%; eczema during the first 12\u00a0months: NS 19%, ST 32%, FA 64%; and aeroallergen sensitization at 4\u00a0years: NS 19.1%, ST 28.6%, FA 44.4%. At birth, a higher proportion of activated regulatory T cells was associated with ST (OR\u00a0=\u00a02.89, 95% CI 1.03\u20108.16, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.045).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Food\u2010sensitized\u2010tolerance in infancy appears to be associated with a similar pattern of exposures, immunity, and outcomes to nonsensitized infants. In addition, we found some evidence that an elevated proportion of activated regulatory T cells at birth was specific to the sensitized\u2010tolerant infants, which may be relevant to suppression of clinical disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.14159","type":"journal-article","created":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T09:51:13Z","timestamp":1576749073000},"page":"1404-1413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Deserters on the atopic march: Risk factors, immune profile and clinical outcomes of food sensitized\u2013tolerant infants"],"prefix":"10.1111","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0773-4037","authenticated-orcid":false,"given":"Lawrence E. K.","family":"Gray","sequence":"first","affiliation":[{"name":"School of Medicine Deakin University Geelong Vic. Australia"},{"name":"Barwon Health Geelong Vic. 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Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D.","family":"Sly","sequence":"additional","affiliation":[{"name":"The Murdoch Children's Research Institute Parkville Vic. Australia"},{"name":"University of Queensland South Brisbane Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarath","family":"Ranganathan","sequence":"additional","affiliation":[{"name":"The Murdoch Children's Research Institute Parkville Vic. Australia"},{"name":"The University of Melbourne Parkville Vic. Australia"},{"name":"The Royal Children's Hospital Parkville Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mimi L. K.","family":"Tang","sequence":"additional","affiliation":[{"name":"The Murdoch Children's Research Institute Parkville Vic. Australia"},{"name":"The University of Melbourne Parkville Vic. Australia"},{"name":"The Royal Children's Hospital Parkville Vic. 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