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Cutaneous T cell\u2013mediated reactions classically occur more than 6\u00a0hours after drug administration and include life\u2010threatening conditions such as toxic epidermal necrolysis, Stevens\u2010Johnson syndrome, and hypersensitivity syndrome. Over the last 20\u00a0years, significant advances have been made in our understanding of the pathogenesis of DHRs with the identification of human leukocyte antigens as predisposing factors. This has led to the development of pharmacogenetic screening tests, such as <jats:italic>HLA\u2010B*57:01<\/jats:italic> in abacavir therapy, which has successfully reduced the incidence of abacavir hypersensitivity reactions. We have completed a PRISMA\u2010compliant systematic review to identify genetic associations that have been reported in DHRs. In total, 105 studies (5554 cases and 123\u00a0548 controls) have been included in the review reporting genetic associations with carbamazepine (n\u00a0=\u00a031), other aromatic antiepileptic drugs (n\u00a0=\u00a024), abacavir (n\u00a0=\u00a011), nevirapine (n\u00a0=\u00a014), trimethoprim\u2010sulfamethoxazole (n\u00a0=\u00a011), dapsone (n\u00a0=\u00a04), allopurinol (n\u00a0=\u00a010), and other drugs (n\u00a0=\u00a05). The most commonly reported genetic variants associated with DHRs are located in human leukocyte antigen genes and genes involved in drug metabolism pathways. Increasing our understanding of genetic variants that contribute to DHRs will allow us to improve diagnosis, develop new treatments, and predict and prevent DHRs in the future.<\/jats:p>","DOI":"10.1111\/all.14174","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T17:19:33Z","timestamp":1578071973000},"page":"1069-1098","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Genetic variants associated with T cell\u2013mediated cutaneous adverse drug reactions: A PRISMA\u2010compliant systematic review\u2014An EAACI position paper"],"prefix":"10.1111","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9731-4529","authenticated-orcid":false,"given":"Abderrahim","family":"Oussalah","sequence":"first","affiliation":[{"name":"INSERM UMR_S 1256 NGERE \u2013 Nutrition, Genetics, and Environmental Risk Exposure Faculty of Medicine of Nancy University of Lorraine Nancy 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