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In this study, we aimed to investigate whether both types of allergen\u2010specific reactivity can coexist in the same individual.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010eight patients with perennial rhinitis symptoms and positive SPT with seasonal allergens only (discrepant group) were subjected to consecutive nasal allergen challenges (NAC) with seasonal (NAC\u2010S) and perennial allergens (NAC\u2010P). A nasal lavage was collected before and after the NACs to measure eosinophil cationic protein (ECP). A basophil activation test (BAT) with seasonal and\/or perennial allergens was performed in ten patients from the discrepant group and in six seasonal allergic rhinitis (SAR), eight perennial local allergic rhinitis (LAR), six nonallergic rhinitis (NAR), and six healthy control (HC) individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients in the discrepant group tested positive in the NAC\u2010S, and 41 of them (85.4%), also in the NAC\u2010P (group A). Conversely, seven patients tested negative in the NAC\u2010P (group B). ECP in the nasal lavage increased after the NAC\u2010P in the group A (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.004), but not in the group B. The BAT with seasonal allergens was positive in 100% of SAR and group A cases, whereas the BAT with perennial allergens was positive in 37.5% and 60% of LAR and group A cases, respectively. All NAR and HC subjects tested negative for the BAT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study shows that nasal reactivity to aeroallergens with and without positive SPT can coexist in the same patient. We propose the term dual allergic rhinitis for this rhinitis phenotype.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.14206","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T15:14:10Z","timestamp":1580310850000},"page":"1689-1698","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Coexistence of nasal reactivity to allergens with and without IgE sensitization in patients with allergic rhinitis"],"prefix":"10.1111","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3774-931X","authenticated-orcid":false,"given":"Ibon","family":"Eguiluz\u2010Gracia","sequence":"first","affiliation":[{"name":"Allergy Unit Hospital Regional Universitario de Malaga Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga\u2010IBIMA and ARADyAL M\u00e1laga 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