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Cohort studies have shown that \u03c93 polyunsaturated fatty acids (PUFAs) in breast milk may have a beneficial effect on the preventing of allergies in infants; however, the underlying mechanisms remain to be investigated. We investigated how the maternal intake of dietary \u03c93 PUFAs affects fatty acid profiles in the breast milk and their pups and reduced the incidence of allergic diseases in the pups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Contact hypersensitivity (CHS) induced by 2,4\u2010dinitrofluorobenzene\u00a0(DNFB) and fluorescein isothiocyanate was applied to the skin in pups reared by mother maintained with diets mainly containing \u03c93 or \u03c96 PUFAs. Skin inflammation, immune cell populations, and expression levels of immunomodulatory molecules in pups and\/or human cell line were investigated by using flow cytometric, immunohistologic, and quantitative RT\u2010PCR analyses. \u03c93 PUFA metabolites in breast milk and infant's serum were evaluated by lipidomics analysis using LC\u2010MS\/MS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We show that maternal intake of linseed oil, containing abundant \u03c93 \u03b1\u2010linolenic acid, resulted in the increased levels of \u03c93 docosapentaenoic acid (DPA) and its 14\u2010lipoxygenation products in the breast milk of mouse dams; these metabolites increased the expression of TNF\u2010related apoptosis\u2010inducing ligand (TRAIL) on plasmacytoid dendritic cells (pDCs) in their pups and thus inhibited infant CHS. Indeed, the administration of DPA\u2010derived 14\u2010lipoxygenation products to mouse pups ameliorated their DNFB CHS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings suggest that an inhibitory mechanism in infant skin allergy is induced through maternal metabolism of dietary \u03c93 PUFAs in mice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.14217","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T12:44:21Z","timestamp":1580993061000},"page":"1939-1955","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Maternal \u03c93 docosapentaenoic acid inhibits infant allergic dermatitis through TRAIL\u2010expressing plasmacytoid dendritic cells in 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