{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T19:58:58Z","timestamp":1788292738276,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,2,23]],"date-time":"2020-02-23T00:00:00Z","timestamp":1582416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Artemisia annua<\/jats:italic>\n                      is an important autumnal pollen allergen for seasonal allergic rhinitis (SAR) in northern China. To date, no study has investigated allergen immunotherapy with\n                      <jats:italic>A\u00a0annua<\/jats:italic>\n                      . We aimed to investigate the efficacy and mechanisms underlying\n                      <jats:italic>A\u00a0annua<\/jats:italic>\n                      \u2010sublingual immunotherapy (SLIT).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a randomized, double\u2010blind, placebo\u2010controlled phase III clinical trial involving 71 SAR patients, randomized to SLIT with\n                      <jats:italic>A\u00a0annua<\/jats:italic>\n                      extract (n\u00a0=\u00a047) or placebo (n\u00a0=\u00a024) for 32\u00a0weeks. Total nasal symptom score (TNSS; primary clinical end point) was evaluated at baseline (peak pollen phase (PPP) in the previous year), initiation of\n                      <jats:italic>A\u00a0annua<\/jats:italic>\n                      \u2010SLIT, 1st PPP during SLIT, end of SLIT and 2nd PPP during follow\u2010up. Blood samples and nasal secretions were collected at beginning and after SLIT for assessment of T cells and inflammatory mediators. Safety was assessed according to adverse events (AEs) reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Artemisia annua<\/jats:italic>\n                      \u2010SLIT significantly reduced TNSS to a greater level from baseline (from 9.45\u00a0\u00b1\u00a01.68 to 6.16\u00a0\u00b1\u00a02.27) than placebo (from 9.29\u00a0\u00b1\u00a02.09 to 9.05\u00a0\u00b1\u00a02.40) at the 1st PPP (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001) and sustained the improvement in symptoms throughout to the 2nd PPP. Preseasonal\n                      <jats:italic>A\u00a0annua<\/jats:italic>\n                      \u2010SLIT for 16\u00a0weeks significantly decreased Th2 cells, increased nTreg and Tr1 cells in blood; and increased cystatin 1 (CST1) in nasal secretion after 16 and 32\u00a0weeks compared with pretreatment. Overall, 17\/47 patients experienced mild local AEs and 2 patients mild systemic AEs, after\n                      <jats:italic>A\u00a0annua<\/jats:italic>\n                      \u2010SLIT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Artemisia annua<\/jats:italic>\n                      \u2010SLIT is an efficacious and safe treatment in patients with\n                      <jats:italic>A\u00a0annua<\/jats:italic>\n                      SAR.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.14218","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T05:00:26Z","timestamp":1581051626000},"page":"2026-2036","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["<i>Artemisia annua<\/i>\n                    \u2010sublingual immunotherapy for seasonal allergic rhinitis: A randomized controlled trial"],"prefix":"10.1111","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8553-812X","authenticated-orcid":false,"given":"Hongfei","family":"Lou","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Beijing TongRen Hospital Capital Medical University Beijing China"},{"name":"Beijing Key Laboratory of Nasal Disease Beijing Institute of Otolaryngology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5755-7684","authenticated-orcid":false,"given":"Yanran","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Beijing TongRen Hospital Capital Medical University Beijing China"},{"name":"Beijing Key Laboratory of Nasal Disease Beijing Institute of Otolaryngology Beijing 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