{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:48:37Z","timestamp":1791272917296,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T00:00:00Z","timestamp":1582761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Coronavirus disease 2019 (COVID\u201019) caused by severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection has been widely spread. We aim to investigate the clinical characteristic and allergy status of patients infected with SARS\u2010CoV\u20102.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Electronic medical records including demographics, clinical manifestation, comorbidities, laboratory data, and radiological materials of 140 hospitalized COVID\u201019 patients, with confirmed result of SARS\u2010CoV\u20102 viral infection, were extracted and analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      An approximately 1:1 ratio of male (50.7%) and female COVID\u201019 patients was found, with an overall median age of 57.0\u00a0years. All patients were community\u2010acquired cases. Fever (91.7%), cough (75.0%), fatigue (75.0%), and gastrointestinal symptoms (39.6%) were the most common clinical manifestations, whereas hypertension (30.0%) and diabetes mellitus (12.1%) were the most common comorbidities. Drug hypersensitivity (11.4%) and urticaria (1.4%) were self\u2010reported by several patients. Asthma or other allergic diseases were not reported by any of the patients. Chronic obstructive pulmonary disease (COPD, 1.4%) patients and current smokers (1.4%) were rare. Bilateral ground\u2010glass or patchy opacity (89.6%) was the most common sign of radiological finding. Lymphopenia (75.4%) and eosinopenia (52.9%) were observed in most patients. Blood eosinophil counts correlate positively with lymphocyte counts in severe (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0.486,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001) and nonsevere (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0.469,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001) patients after hospital admission. Significantly higher levels of D\u2010dimer, C\u2010reactive protein, and procalcitonin were associated with severe patients compared to nonsevere patients (all\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Detailed clinical investigation of 140 hospitalized COVID\u201019 cases suggests eosinopenia together with lymphopenia may be a potential indicator for diagnosis. Allergic diseases, asthma, and COPD are not risk factors for SARS\u2010CoV\u20102 infection. Older age, high number of comorbidities, and more prominent laboratory abnormalities were associated with severe patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.14238","type":"journal-article","created":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T02:04:41Z","timestamp":1582164281000},"page":"1730-1741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2757,"title":["Clinical characteristics of 140 patients infected with SARS\u2010CoV\u20102 in Wuhan, China"],"prefix":"10.1111","volume":"75","author":[{"given":"Jin-jin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Allergology Zhongnan Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Allergology Zhongnan Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-yuan","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Radiology Zhongnan Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-dong","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Second Hospital of Hebei Medical University Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-bin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Zhongnan Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-qin","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease No. 7 Hospital of Wuhan Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8020-019X","authenticated-orcid":false,"given":"Cezmi A.","family":"Akdis","sequence":"additional","affiliation":[{"name":"Swiss Institute of Allergy and Asthma Research (SIAF) University of Zurich Davos Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-dong","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Allergology Zhongnan Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30211-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1585"},{"key":"e_1_2_9_5_1","unstructured":"GuanW NiZ HuY et al.Clinical characteristics of 2019 novel coronavirus infection in China. medRxiv 2020:2020.02.06.20020974."},{"key":"e_1_2_9_6_1","unstructured":"World Health Organization (WHO).Coronavirus disease (COVID\u20102019) situation reports.https:\/\/www.who.int\/emergencies\/diseases\/novel-coronavirus-2019\/situation-reports. 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