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However, adoptive transfer of naturally occurring Treg (tTreg) cells or peripherally derived Treg (pTreg) cells in asthmatic mouse models did not yield satisfactory results in any previous studies. Here, we review the recent progress in the identification and plasticity of tTreg and pTreg cells in Th2\u2013biased airway diseases and summarize the factors affecting the stability and function of Treg cells. This review may serve as foundation for understanding the molecular mechanisms underlying the stability of tTreg and pTreg cells and development of effective strategies for treating allergic airway diseases.<\/jats:p>","DOI":"10.1111\/all.14257","type":"journal-article","created":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T07:34:55Z","timestamp":1583220895000},"page":"1918-1926","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Stability of regulatory T cells in T helper 2\u2013biased allergic airway diseases"],"prefix":"10.1111","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1709-5179","authenticated-orcid":false,"given":"Feng","family":"Lan","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Beijing TongRen Hospital Capital Medical University Beijing China"},{"name":"Beijing Key Laboratory of Nasal Disease Beijing Institute of Otolaryngology 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