{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T16:46:25Z","timestamp":1788540385603,"version":"build-2803163510"},"reference-count":9,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T00:00:00Z","timestamp":1584921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005620","name":"North Carolina GlaxoSmithKline Foundation","doi-asserted-by":"publisher","award":["GSK ID: MEA115588; NCT01691521"],"award-info":[{"award-number":["GSK ID: MEA115588; NCT01691521"]}],"id":[{"id":"10.13039\/100005620","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1111\/all.14266","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T07:30:16Z","timestamp":1583739016000},"page":"2085-2088","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Eosinophil\u2010derived neurotoxin and clinical outcomes with mepolizumab in severe eosinophilic asthma"],"prefix":"10.1111","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0619-7927","authenticated-orcid":false,"given":"Peter","family":"Howarth","sequence":"first","affiliation":[{"name":"Global Medical Global Specialty and Primary Care, GSK House Brentford Middlesex UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Quirce","sequence":"additional","affiliation":[{"name":"Department of Allergy Hospital La Paz Institute for Health Research (IdiPAZ) Madrid Spain"},{"name":"CIBER de Enfermedades Respiratorias (CIBERES) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Papi","sequence":"additional","affiliation":[{"name":"Section of Cardiorespiratory and Internal Medicine Department of Medical Sciences University of Ferrara Ferrara Italy"},{"name":"S. Anna University Hospital Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot","family":"Israel","sequence":"additional","affiliation":[{"name":"Harvard Medical School and Asthma Research Center Brigham and Women\u2019s Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Mallett","sequence":"additional","affiliation":[{"name":"Biostatistics GSK Uxbridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart","family":"Bates","sequence":"additional","affiliation":[{"name":"Respiratory Discovery Medicine GSK Stevenage UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Yancey","sequence":"additional","affiliation":[{"name":"Respiratory Therapeutic Area GSK Research Triangle Park NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7039-4621","authenticated-orcid":false,"given":"Frank C.","family":"Albers*","sequence":"additional","affiliation":[{"name":"Respiratory Medical Franchise GSK Research Triangle Park NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5238-0656","authenticated-orcid":false,"given":"Namhee","family":"Kwon","sequence":"additional","affiliation":[{"name":"Respiratory Medical Franchise GSK London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,23]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03929.x"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12792"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2015.36.3884"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R113.546218"},{"key":"e_1_2_3_6_1","volume-title":"NUCALA US prescribing information","author":"GlaxoSmithKline"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(17)30125-X"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1403290"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60988-X"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2016.01.003"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.14266","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.14266","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/all.14266","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.14266","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T20:37:59Z","timestamp":1692650279000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.14266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,23]]},"references-count":9,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1111\/all.14266"],"URL":"https:\/\/doi.org\/10.1111\/all.14266","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,23]]},"assertion":[{"value":"2019-11-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}