{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:02:10Z","timestamp":1790841730216,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T00:00:00Z","timestamp":1587081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["SZSM201612014"],"award-info":[{"award-number":["SZSM201612014"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The clinical characteristics of novel coronavirus disease (COVID\u20102019) patients outside the epicenter of Hubei Province are less understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed the epidemiological and clinical features of all COVID\u20102019 cases in the only referral hospital in Shenzhen City, China, from January 11, 2020, to February 6, 2020, and followed until March 6, 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 298 confirmed cases, 233 (81.5%) had been to Hubei, while 42 (14%) did not have a clear travel history. Only 218 (73.15%) cases had a fever as the initial symptom. Compared with the nonsevere cases, severe cases were associated with older age, those with underlying diseases, and higher levels of C\u2010reactive protein, interleukin\u20106, and erythrocyte sedimentation rate. Slower clearance of the virus was associated with a higher risk of progression to critical condition. As of March 6, 2020, 268 (89.9%) patients were discharged and the overall case fatality ratio was 1.0%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In a designated hospital outside Hubei Province, COVID\u20102019 patients could be effectively managed by properly using the existing hospital system. Mortality may be lowered when cases are relatively mild, and there are sufficient medical resources to care and treat the disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.14309","type":"journal-article","created":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T12:08:45Z","timestamp":1585829325000},"page":"1742-1752","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":330,"title":["COVID\u201019 in a designated infectious diseases hospital outside Hubei Province, China"],"prefix":"10.1111","volume":"75","author":[{"given":"Qingxian","family":"Cai","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Infectious Diseases The Third People\u2019s Hospital of Shenzhen The Second Affiliated Hospital of Southern University of Science and Technology Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deliang","family":"Huang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Infectious Diseases The Third People\u2019s Hospital of Shenzhen The Second Affiliated Hospital of Southern University of Science and Technology Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengcheng","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Shenzhen People\u2019s Hospital The First Affiliated Hospital of Southern University of Science and Technology Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Yu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Infectious Diseases The Third People\u2019s Hospital of Shenzhen The Second Affiliated Hospital of Southern University of Science and Technology Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibin","family":"Zhu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Infectious Diseases The Third People\u2019s Hospital of Shenzhen The Second Affiliated Hospital of Southern University of Science and Technology Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Xia","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Infectious Diseases The Third People\u2019s Hospital of Shenzhen The Second Affiliated Hospital of Southern University of Science and Technology Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinan","family":"Su","sequence":"additional","affiliation":[{"name":"School of Medicine Southern University of Science and Technology Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghua","family":"Ma","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Infectious Diseases The Third People\u2019s Hospital of Shenzhen The Second Affiliated Hospital of Southern University of Science and Technology Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Infectious Diseases The Third People\u2019s Hospital of Shenzhen The Second Affiliated Hospital of Southern University of Science and Technology Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Li","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Infectious Diseases The Third People\u2019s Hospital of Shenzhen The Second Affiliated Hospital of Southern University of Science and Technology Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"He","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Infectious Diseases The Third People\u2019s Hospital of Shenzhen The Second Affiliated Hospital of Southern University of Science and Technology Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Liu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Infectious Diseases The Third People\u2019s Hospital of Shenzhen The Second Affiliated Hospital of Southern University of Science and Technology Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Fu","sequence":"additional","affiliation":[{"name":"School of Medicine Southern University of Science and Technology Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9744-792X","authenticated-orcid":false,"given":"Jun","family":"Chen","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Infectious Diseases The Third People\u2019s Hospital of Shenzhen The Second Affiliated Hospital of Southern University of Science and Technology Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,17]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization.Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected: interim guidance. Published January 28 2020.https:\/\/www.who.int\/publications\u2010detail\/clinical\u2010management\u2010of\u2010severe\u2010acute\u2010respiratory\u2010infection\u2010when\u2010novel\u2010coronavirus\u2010(ncov)\u2010infection\u2010is\u2010suspected. Accessed January 31 2020."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001316"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","unstructured":"JonathanMR BridgenJRE CummingsDAT HoA JewellCP.Novel coronavirus 2019\u2010nCoV: early estimation of epidemiological parameters and epidemic predictions. medrxiv.1.24.2020.https:\/\/doi.org\/10.1101\/2020.01.23.20018549. 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