{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:49:23Z","timestamp":1791946163626,"version":"4.3.4"},"reference-count":67,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T00:00:00Z","timestamp":1589500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["PO1AI1089473"],"award-info":[{"award-number":["PO1AI1089473"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["RO1AI138348"],"award-info":[{"award-number":["RO1AI138348"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["5T32HL007517\u201030"],"award-info":[{"award-number":["5T32HL007517\u201030"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Respiratory syncytial virus (RSV) affects most infants early in life and is associated with increased asthma risk. The specific mechanism remains unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the role of uric acid (UA) and IL\u20101\u03b2 in RSV immunopathology and asthma predisposition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Tracheal aspirates from human infants with and without RSV were collected and analyzed for pro\u2010IL\u20101\u03b2 mRNA and protein to establish a correlation in human disease. Neonatal mouse models of RSV were employed, wherein mice infected at 6\u20107\u00a0days of life were analyzed at 8\u00a0days postinfection, 5\u00a0weeks postinfection, or after a chronic cockroach allergen asthma model. A xanthine oxidase inhibitor or IL\u20101 receptor antagonist was administered during RSV infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Human tracheal aspirates from RSV\u2010infected infants showed elevated pro\u2010IL\u20101\u03b2 mRNA and protein. Inhibition of UA or IL\u20101\u03b2 during neonatal murine RSV infection decreased mucus production, reduced cellular infiltrates to the lung (especially ILC2s), and decreased type 2 immune responses. Inhibition of either UA or IL\u20101\u03b2 during RSV infection led to chronic reductions in pulmonary immune cell composition and reduced type 2 immune responses and reduced similar responses after challenge with cockroach antigen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Inhibiting UA and IL\u20101\u03b2 during RSV infection ameliorates RSV immunopathology, reduces the consequences of allergen\u2010induced asthma, and presents new therapeutic targets to reduce early\u2010life viral\u2010induced asthma development.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.14310","type":"journal-article","created":{"date-parts":[[2020,4,11]],"date-time":"2020-04-11T03:21:57Z","timestamp":1586575317000},"page":"2279-2293","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Inhibition of uric acid or IL\u20101\u03b2 ameliorates respiratory syncytial virus immunopathology and development of asthma"],"prefix":"10.1111","volume":"75","author":[{"suffix":"IV","given":"Charles F.","family":"Schuler","sequence":"first","affiliation":[{"name":"Division of Allergy and Clinical Immunology Department of Internal Medicine University of Michigan Ann Arbor MI USA"},{"name":"Mary H. Weiser Food Allergy Center University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie\u2010Anne","family":"Malinczak","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon K. K.","family":"Best","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan B.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Rasky","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2098-8373","authenticated-orcid":false,"given":"Catherine","family":"Ptaschinski","sequence":"additional","affiliation":[{"name":"Mary H. 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