{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:36:28Z","timestamp":1777581388600,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T00:00:00Z","timestamp":1589760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dupilumab is an anti\u2010IL\u20104R\u03b1 antibody used in the treatment of patients with moderate\u2010to\u2010severe atopic dermatitis (msAD).<\/jats:p><jats:p>This study explored the potential benefit of dupilumab in perennial allergic rhinoconjunctivitis (PAR) and perennial allergic asthma (PAA) caused by indoor allergens in adults with msAD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multicentric, prospective, observational, real\u2010life study included adult patients with msAD who had been treated with dupilumab in 16 Italian care centres. Efficacy outcomes regarding AD, PAR and PAA were collected at baseline and 16\u00a0weeks. Safety was also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We enrolled 123 patients with msAD. Between baseline and 16\u00a0weeks of treatment, the following measurements decreased statistically significantly: Eczema Area and Severity Index, SCOring AD, Patient\u2010Oriented Eczema Measure, pruritus score, sleep score, Dermatology Life Quality Index and IgE.<\/jats:p><jats:p>Dupilumab treatment in patients with comorbid PAR (n\u00a0=\u00a041) was associated with significant improvements in PAR disease control (measured using a Rhinitis Control Scoring System) and in PAR Quality of life (QoL) (measured using the Rhinoconjunctivitis QoL Questionnaire scores).<\/jats:p><jats:p>In 32 patients with comorbid PAA, dupilumab significantly improved PAA control (measured using the Asthma Control Test and five\u2010item Asthma Control Questionnaire scores) and disease\u2010related QoL (measured using the Asthma QoL Questionnaire scores). Thirty\u2010five patients (28.5%) developed conjunctivitis during the study period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results support the benefits of dupilumab for adult patients with PAR and\/or PAA associated with msAD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.14338","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T06:31:54Z","timestamp":1587709914000},"page":"2653-2661","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Efficacy of dupilumab in atopic comorbidities associated with moderate\u2010to\u2010severe adult atopic dermatitis"],"prefix":"10.1111","volume":"75","author":[{"given":"Eustachio","family":"Nettis","sequence":"first","affiliation":[{"name":"Department of Emergency and Organ Transplantation School and Chair of Allergology and Clinical Immunology University of Bari \u2010 Aldo Moro Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5640-6446","authenticated-orcid":false,"given":"Vincenzo","family":"Patella","sequence":"additional","affiliation":[{"name":"Division of Allergy and Clinical Immunology Department of Medicine ASL Salerno Santa Maria della Speranza\" Hospital Salerno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Lombardo","sequence":"additional","affiliation":[{"name":"Division of Dermatology \"U.O. 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