{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:49:38Z","timestamp":1790794178475,"version":"4.1.0"},"reference-count":161,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T00:00:00Z","timestamp":1592265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Airway epithelial barrier dysfunction is frequently observed in asthma and may have important implications. The physical barrier function of the airway epithelium is tightly interwoven with its immunomodulatory actions, while abnormal epithelial repair responses may contribute to remodelling of the airway wall. We propose that abnormalities in the airway epithelial barrier play a crucial role in the sensitization to allergens and pathogenesis of asthma. Many of the identified susceptibility genes for asthma are expressed in the airway epithelium, supporting the notion that events at the airway epithelial surface are critical for the development of the disease. However, the exact mechanisms by which the expression of epithelial susceptibility genes translates into a functionally altered response to environmental risk factors of asthma are still unknown. Interactions between genetic factors and epigenetic regulatory mechanisms may be crucial for asthma susceptibility. Understanding these mechanisms may lead to identification of novel targets for asthma intervention by targeting the airway epithelium. Moreover, exciting new insights have come from recent studies using single\u2010cell RNA sequencing (scRNA\u2010Seq) to study the airway epithelium in asthma. This review focuses on the role of airway epithelial barrier function in the susceptibility to develop asthma and novel insights in the modulation of epithelial cell dysfunction in asthma.<\/jats:p>","DOI":"10.1111\/all.14421","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T18:06:40Z","timestamp":1590602800000},"page":"1902-1917","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":309,"title":["Epithelial cell dysfunction, a major driver of asthma development"],"prefix":"10.1111","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1260-8932","authenticated-orcid":false,"given":"Irene H.","family":"Heijink","sequence":"first","affiliation":[{"name":"Department of Pathology &amp; Medical Biology GRIAC Research Institute University Medical Center Groningen University of Groningen Groningen The Netherlands"},{"name":"Department of Pulmonology University Medical Center Groningen University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4867-4026","authenticated-orcid":false,"given":"Virinchi N. S.","family":"Kuchibhotla","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Medical Biology GRIAC Research Institute University Medical Center Groningen University of Groningen Groningen The Netherlands"},{"name":"School of Biomedical Sciences and Pharmacy University of Newcastle Callaghan NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam P.","family":"Roffel","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Medical Biology GRIAC Research Institute University Medical Center Groningen University of Groningen Groningen The Netherlands"},{"name":"Department of Respiratory Medicine Laboratory for Translational Research in Obstructive Pulmonary Diseases Ghent University Hospital Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Maes","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Laboratory for Translational Research in Obstructive Pulmonary Diseases Ghent University Hospital Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darryl A.","family":"Knight","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and Pharmacy University of Newcastle Callaghan NSW Australia"},{"name":"UBC Providence Health Care Research Institute Vancouver BC Canada"},{"name":"Department of Anesthesiology, Pharmacology and Therapeutics University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Sayers","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine National Institute for Health Research Nottingham Biomedical Research Centre University of Nottingham Biodiscovery Institute University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn C.","family":"Nawijn","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Medical Biology GRIAC Research Institute University Medical Center Groningen University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,16]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"The Global Asthma Report 2018;2018.http:\/\/www.globalasthmareport.org\/. Accessed January 14 2020."},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12296"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra054308"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201506-377AW"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00158"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0393-7"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12777"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.90209.2008"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2005-0332OC"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2009-0304OC"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2010.10.011"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.5415\/apallergy.2014.4.4.187"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2020.12.2.338"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.05.006"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2737"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00130004"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-016-2566-8"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.201102-018MW"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2011-0031OC"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.05.038"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)33311-1"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2011.03.004"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.12.7678"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600605"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2007.07.012"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1139\/Y08-004"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2013-0124OC"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00065809"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13619"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-31500-8"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1593\/neo.121088"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e32834ec6eb"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00125809"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016175"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200811-1730OC"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2020\u20100104ED"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2019-0069OC"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1985.131.4.599"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2014.934813"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14216"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201311-1982LE"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00046.2006"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12202"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2011-200606"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20133222"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.02.038"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep39559"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.03.050"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.12.669"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2018.12.012"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005318"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041901"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12329"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.07.031"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02074-10"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200801-136OC"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13097"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2019.109523"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2017-0200TR"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2018.04.002"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-018-8712-1"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13178"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2019.02.082"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.11.044"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.11.016"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13436"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12683"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2014-0381OC"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2010.191"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9804"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.10.160"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.01173.x"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.12.070"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30389-8"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0168680"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2830"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.01.052"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-185207"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163967"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00346.2014"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2019-0237OC"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1610433113"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.11.040"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.05.036"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.10.023"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707413104"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02079-2019"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.2217\/epi.15.53"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.05.011"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes10110932"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.12.911"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2017.86"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0468-5"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14027"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30466-1"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11058-3"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.07.036"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2020.1686977"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01280-2019"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0205275"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13473"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755-8794-7-37"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.03.046"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-016-0434-4"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201201-0027OC"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.912412"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1080\/01902148.2018.1533051"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12551"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111659"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13413"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.899955"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.02.018"},{"issue":"6","key":"e_1_2_13_114_1","first-page":"2005","article-title":"TGF\u2010beta\u2010induced long non\u2010coding RNA MIR155HG promotes the progression and EMT of laryngeal squamous cell carcinoma by regulating the miR\u2010155\u20105p\/SOX10 axis","volume":"54","author":"Cui W","year":"2019","journal-title":"Int J Oncol"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149257"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.04.044"},{"issue":"7","key":"e_1_2_13_117_1","first-page":"3463","article-title":"miR\u2010330 regulates interleukin\u201013\u2010induced MUC5AC secretion by targeting Munc18b in human bronchial epithelial cells","volume":"11","author":"Su Y","year":"2018","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2018-0156OC"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14008"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27540"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0698-6"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0394-6"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2018-0416TR"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.27041"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00841-2016"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2018.00324"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2015.08.014"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15715"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-10-100"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2013-203520"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.02.003"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050466"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200906-0937OC"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3985"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-052016-100401"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.05.013"},{"issue":"1","key":"e_1_2_13_137_1","first-page":"70","article-title":"Filaggrin polymorphism Pro478Ser is associated with the severity of atopic dermatitis and colonization by staphylococcal aureus","volume":"26","author":"Lopes C","year":"2016","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_13_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2013.90"},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0906312"},{"key":"e_1_2_13_140_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.87871"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.10.030"},{"key":"e_1_2_13_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni805"},{"key":"e_1_2_13_143_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02399-2016"},{"key":"e_1_2_13_144_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2014.126"},{"key":"e_1_2_13_145_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023714"},{"key":"e_1_2_13_146_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200810-1621OC"},{"key":"e_1_2_13_147_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2018-0220OC"},{"key":"e_1_2_13_148_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI126402"},{"key":"e_1_2_13_149_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201406-1039OC"},{"key":"e_1_2_13_150_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044213"},{"key":"e_1_2_13_151_1","doi-asserted-by":"publisher","DOI":"10.1159\/000494241"},{"key":"e_1_2_13_152_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06014"},{"key":"e_1_2_13_153_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601848"},{"key":"e_1_2_13_154_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1303047"},{"key":"e_1_2_13_155_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI130860"},{"key":"e_1_2_13_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.06.122"},{"issue":"2","key":"e_1_2_13_157_1","first-page":"535","article-title":"Investigating the regulatory role of ORMDL3 in airway barrier dysfunction using in vivo and in vitro models","volume":"44","author":"Yang R","year":"2019","journal-title":"Int J Mol Med"},{"key":"e_1_2_13_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.03.014"},{"key":"e_1_2_13_159_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12327"},{"key":"e_1_2_13_160_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00194710"},{"key":"e_1_2_13_161_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2011-200508"},{"key":"e_1_2_13_162_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12730"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fall.14421","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.14421","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/all.14421","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.14421","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T16:38:31Z","timestamp":1692635911000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.14421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,16]]},"references-count":161,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1111\/all.14421"],"URL":"https:\/\/doi.org\/10.1111\/all.14421","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,16]]},"assertion":[{"value":"2020-03-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}