{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:00:10Z","timestamp":1792515610960,"version":"4.5.0"},"reference-count":77,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T00:00:00Z","timestamp":1598227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Morbidity and mortality from COVID\u201019 caused by novel coronavirus SARS\u2010CoV\u20102 is accelerating worldwide, and novel clinical presentations of COVID\u201019 are often reported. The range of human cells and tissues targeted by SARS\u2010CoV\u20102, its potential receptors and associated regulating factors are still largely unknown. The aim of our study was to analyze the expression of known and potential SARS\u2010CoV\u20102 receptors and related molecules in the extensive collection of primary human cells and tissues from healthy subjects of different age and from patients with risk factors and known comorbidities of COVID\u201019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed RNA sequencing and explored available RNA\u2010Seq databases to study gene expression and co\u2010expression of ACE2, CD147 (\n                      <jats:italic>BSG<\/jats:italic>\n                      ), and CD26 (\n                      <jats:italic>DPP4<\/jats:italic>\n                      ) and their direct and indirect molecular partners in primary human bronchial epithelial cells, bronchial and skin biopsies, bronchoalveolar lavage fluid, whole blood, peripheral blood mononuclear cells (PBMCs), monocytes, neutrophils, DCs, NK cells, ILC1, ILC2, ILC3, CD4\n                      <jats:sup>+<\/jats:sup>\n                      and CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells, B cells, and plasmablasts. We analyzed the material from healthy children and adults, and from adults in relation to their disease or COVID\u201019 risk factor status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>ACE2<\/jats:italic>\n                      and\n                      <jats:italic>TMPRSS2<\/jats:italic>\n                      were coexpressed at the epithelial sites of the lung and skin, whereas CD147 (\n                      <jats:italic>BSG<\/jats:italic>\n                      ), cyclophilins (\n                      <jats:italic>PPIA<\/jats:italic>\n                      and\n                      <jats:italic>PPIB<\/jats:italic>\n                      ), CD26 (\n                      <jats:italic>DPP4<\/jats:italic>\n                      ), and related molecules were expressed in both epithelium and in immune cells. We also observed a distinct age\u2010related expression profile of these genes in the PBMCs and T cells from healthy children and adults. Asthma, COPD, hypertension, smoking, obesity, and male gender status generally led to the higher expression of ACE2\u2010 and CD147\u2010related genes in the bronchial biopsy, BAL, or blood. Additionally, CD147\u2010related genes correlated positively with age and BMI. Interestingly, we also observed higher expression of CD147\u2010related genes in the lesional skin of patients with atopic dermatitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our data suggest different receptor repertoire potentially involved in the SARS\u2010CoV\u20102 infection at the epithelial barriers and in the immune cells. Altered expression of these receptors related to age, gender, obesity and smoking, as well as with the disease status, might contribute to COVID\u201019 morbidity and severity patterns.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.14429","type":"journal-article","created":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T12:14:46Z","timestamp":1591272886000},"page":"2829-2845","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":462,"title":["Distribution of ACE2, CD147, CD26, and other SARS\u2010CoV\u20102 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID\u201019 risk factors"],"prefix":"10.1111","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7341-9764","authenticated-orcid":false,"given":"Urszula","family":"Radzikowska","sequence":"first","affiliation":[{"name":"Swiss Institute of Allergy and Asthma Research (SIAF) University of 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