{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T09:07:28Z","timestamp":1784797648133,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T00:00:00Z","timestamp":1595894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>While the clinical characteristics and outcomes of asthma\u2010chronic obstructive pulmonary disease (COPD) overlap (ACO) have been frequently compared with those of COPD or asthma, the prevalence and features of ACO in patients with severe asthma are unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Evaluation of the prevalence and clinical features of ACO using the Korean severe asthma registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>At the time of registration, ACO was determined in patients with severe asthma by attending specialists. Patients were classified into ACO and non\u2010ACO groups, and the demographic and clinical characteristics of these two groups were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 482 patients with severe asthma, 23.7% had ACO. Patients in the ACO group were more likely to be male (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), older (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), and ex\u2010 or current smokers (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) compared with those in the non\u2010ACO group. Patients in the ACO group had lower mean forced expiratory volume in 1\u00a0second (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and blood eosinophil percentage (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.006), but higher blood neutrophil percentage (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.027) than those in the non\u2010ACO group. The ACO group used more inhaled long\u2010acting muscarinic antagonist (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), methylxanthine (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001), or sustained systemic corticosteroid (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.002). In addition, unscheduled emergency department visits due to exacerbation were more frequent in the ACO group (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.006).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among patients with severe asthma, those with ACO were older, predominantly male, and were more likely to have a smoking history than those with asthma only. Patients with ACO used more systemic corticosteroid and had more frequent exacerbations related to emergency department visits than those with severe asthma only.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.14483","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T15:31:10Z","timestamp":1594049470000},"page":"223-232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Characteristics of Specialist\u2010Diagnosed Asthma\u2010COPD Overlap in Severe Asthma: Observations from the Korean Severe Asthma Registry (KoSAR)"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1269-0913","authenticated-orcid":false,"given":"Hyun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Hanyang University College of Medicine Seoul 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Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy and Critical Care Medicine Department of Internal Medicine Seoul St Mary\u2019s Hospital College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7961-742X","authenticated-orcid":false,"given":"Ga\u2010Young","family":"Ban","sequence":"additional","affiliation":[{"name":"Department of Pulmonary, Allergy and Critical Care Medicine Kangdong Sacred Heart Hospital Hallym University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1775-3733","authenticated-orcid":false,"given":"Min\u2010Hye","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of Medicine, Ewha Womans University Seoul 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