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COVID\u201019 affects primarily the respiratory airways leading to dry cough, fever, myalgia, headache, fatigue, and diarrhea and can end up in interstitial pneumonia and severe respiratory failure. Reports about the manifestation of various skin lesions and lesions of the vascular system in some subgroups of SARS\u2010CoV\u20102\u2010positive patients as such features outside the respiratory sphere, are rapidly emerging. Vesicular, urticarial, and maculopapular eruptions and livedo, necrosis, and other vasculitis forms have been reported most frequently in association with SARS\u2010CoV\u20102 infection. In order to update information gained, we provide a systematic overview of the skin lesions described in COVID\u201019 patients, discuss potential causative factors, and describe differential diagnostic evaluations. Moreover, we summarize current knowledge about immunologic, clinical, and histologic features of virus\u2010 and drug\u2010induced lesions of the skin and changes to the vascular system in order to transfer this knowledge to potential mechanisms induced by SARS\u2010CoV\u20102.<\/jats:p>","DOI":"10.1111\/all.14498","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T14:51:14Z","timestamp":1594651874000},"page":"698-713","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["SARS\u2010CoV\u20102, COVID\u201019, skin and immunology \u2013 What do we know so far?"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8146-8673","authenticated-orcid":false,"given":"Natalijia","family":"Novak","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital of Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenming","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital of Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam C.","family":"Naegeli","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Zurich  Zurich Switzerland"},{"name":"Faculty of Medicine University Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Galvan","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology M\u00f3stoles Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Kolm\u2010Djamei","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Zurich  Zurich Switzerland"},{"name":"Faculty of Medicine University Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Br\u00fcggen","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Zurich  Zurich Switzerland"},{"name":"Faculty of Medicine University Zurich  Zurich Switzerland"},{"name":"Hochgebirgsklinik Davos  Davos Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Cabanillas","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital of Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3215-3370","authenticated-orcid":false,"given":"Peter","family":"Schmid\u2010Grendelmeier","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Zurich  Zurich Switzerland"},{"name":"Faculty of Medicine University Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Catala","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Plat\u00f3 Hospital  Barcelona Spain  <!--Query ID=\"q4\" Text=\"AUTHOR: Please check that authors and their affiliations are correct.\"-->"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0311-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001017"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14289"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25757"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0820-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.052"},{"key":"e_1_2_6_8_1","article-title":"Angiotensin\u2010converting enzyme\u20102 (ACE2), SARS\u2010CoV\u20102 and pathophysiology of coronavirus disease 2019 (COVID\u201019)","volume":"2020","author":"Bourgonje AR","journal-title":"J Pathol."},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14360"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14449"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14364"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb2507"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1116480"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600640"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","unstructured":"DujifPHG. 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