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Demographic and clinical information were extracted from the medical records. Lung tissue sections from patients suffering from lung cancer were used for immunohistochemistry study of angiotensin\u2010converting enzyme II (ACE2) expression. BEAS\u20102B cell line was stimulated with various cytokines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this cohort, 21 subjects (2.2%) had COPD and 22 (2.3%) had asthma. After adjusting for confounding factors, COPD patients had higher risk of developing severe illness (OR: 23.433; 95% CI 1.525\u2010360.135; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01) and acute respiratory distress syndrome (OR: 19.762; 95% CI 1.461\u2010267.369; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.025) than asthmatics. COPD patients, particularly those with severe COVID\u201019, had lower counts of CD4<jats:sup>+<\/jats:sup> T and CD8<jats:sup>+<\/jats:sup> T cells and B cells and higher levels of TNF\u2010\u03b1, IL\u20102 receptor, IL\u201010, IL\u20108, and IL\u20106 than asthmatics. COPD patients had increased, whereas asthmatics had decreased ACE2 protein expression in lower airways, compared with that in control subjects without asthma and COPD. IL\u20104 and IL\u201013 downregulated, but TNF\u2010\u03b1, IL\u201012, and IL\u201017A upregulated ACE2 expression in BEAS\u20102B cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with asthma and COPD likely have different risk of severe COVID\u201019, which may be associated with different ACE2 expression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.14517","type":"journal-article","created":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T15:35:55Z","timestamp":1595864155000},"page":"483-496","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":127,"title":["Distinct effects of asthma and COPD comorbidity on disease expression and outcome in patients with COVID\u201019"],"prefix":"10.1111","volume":"76","author":[{"given":"Jia","family":"Song","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Neurology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 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