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The upper and lower airways are lined with respiratory epithelium that plays a vital role in immune surveillance and modulation as the first line of defense to various infective pathogens, allergens, and physical insults. Recently, there is a common hypothesis emphasizing epithelium\u2010derived cytokines, namely IL\u201025, IL\u201033, and TSLP, as key regulatory factors that link in immune\u2010pathogenic mechanisms of allergic rhinitis (AR), chronic rhinosinusitis (CRS), and asthma, mainly involving in type 2 inflammatory responses and linking innate and adaptive immunities. Herein, we review studies that elucidated the role of epithelium\u2010derived triple cytokines in both upper and lower airways with the purpose of expediting better clinical treatments and managements of AR, CRS, asthma, and other associated allergic diseases via applications of the modulators of these cytokines.<\/jats:p>","DOI":"10.1111\/all.14526","type":"journal-article","created":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T04:59:38Z","timestamp":1596257978000},"page":"2794-2804","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":254,"title":["Role of IL\u201025, IL\u201033, and TSLP in triggering united airway diseases toward type 2 inflammation"],"prefix":"10.1111","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5317-1271","authenticated-orcid":false,"given":"Haiyu","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Allergy Center The Fifth Affiliated Hospital of 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