{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T02:06:34Z","timestamp":1789005994523,"version":"build-2803163510"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T00:00:00Z","timestamp":1599436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This systematic review evaluates the efficacy and safety of omalizumab for chronic spontaneous urticaria (CSU). PubMed, Embase, and Cochrane Library were searched for RCTs. Critical and important CSU\u2010related outcomes were considered. The risk of bias and the certainty of the evidence were assessed using GRADE. Ten RCTs including 1620 subjects aged 12 to 75\u00a0years old treated with omalizumab for 16 to 40\u00a0weeks were evaluated. Omalizumab 150\u00a0mg does not result in clinically meaningful improvement (high certainty) of the urticaria activity score (UAS)7 (mean difference (MD) \u22125; 95%CI \u22127.75 to \u22122.25), and the itch severity score (ISS)7 (MD \u22122.15; 95% CI \u22123.2 to \u22121.1) does not increase (moderate certainty) quality of life (QoL) (Dermatology Life Quality Index (DLQI); MD \u22122.01; 95%CI \u22123.22 to \u22120.81) and decreases (moderate certainty) rescue medication use (MD \u22121.68; 95%CI \u22122.95 to \u22120.4). Omalizumab 300\u00a0mg results in clinically meaningful improvements (moderate certainty) of the UAS7 (MD \u221211.05; 95%CI \u221212.87 to \u22129.24), the ISS7 (MD \u22124.45; 95%CI \u22125.39 to \u22123.51), and QoL (high certainty) (DLQI; MD \u22124.03; 95% CI \u22125.56 to \u22122.5) and decreases (moderate certainty) rescue medication use (MD \u22122.04; 95%CI \u22123.19 to \u22120.88) and drug\u2010related serious AEs (RR 0.77; 95%CI 0.20 to 2.91).<\/jats:p>","DOI":"10.1111\/all.14547","type":"journal-article","created":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T09:08:24Z","timestamp":1596791304000},"page":"59-70","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":91,"title":["Efficacy and safety of treatment with omalizumab for chronic spontaneous urticaria: A systematic review for the EAACI Biologicals 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