{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:46:26Z","timestamp":1793126786986,"version":"4.5.0"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T00:00:00Z","timestamp":1600128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The association between grass pollen exposure and early markers of asthma exacerbations such as lung function changes and increase in airway inflammation is limited. We investigated the associations between short\u2010term grass pollen exposure and lung function and airway inflammation in a community\u2010based sample, and whether any such associations were modified by current asthma, current hay fever, pollen sensitization, age, and other environmental factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cross\u2010sectional and short\u2010term analyses of data from the Melbourne Atopy Cohort Study (MACS) participants (n\u00a0=\u00a0936). Lung function was assessed using spirometry. Airway inflammation was assessed by fractional exhaled nitric oxide (FeNO) and exhaled breath condensate pH and nitrogen oxides (NOx). Daily pollen counts were collected using a volumetric spore trap. The associations were examined by linear regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Higher ambient levels of grass pollen 2\u00a0days before (lag 2) were associated with lower mid\u2010forced expiratory flow (FEF<jats:sub>25%\u201075%<\/jats:sub>) and FEV<jats:sub>1<\/jats:sub>\/FVC ratio (Coef. [95% CI]\u00a0=\u00a0\u2212119 [\u2212226, \u221211]\u00a0mL\/s and \u22121.0 [\u22123.0, \u22120.03] %, respectively) and also 3\u00a0days before (lag 3). Increased levels of grass pollen a day before (lag 1) were associated with increased FeNO (4.35 [\u22120.1, 8.7] ppb) and also at lag 2. Adverse associations between pollen and multiple outcomes were greater in adults with current asthma, hay fever, and pollen sensitization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Grass pollen exposure was associated with eosinophilic airway inflammation 1\u20102\u00a0days after exposure and airway obstruction 2\u20103\u00a0days after exposure. Adults and individuals with asthma, hay fever, and pollen sensitization may be at higher risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.14566","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T09:54:41Z","timestamp":1598608481000},"page":"1136-1146","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Is short\u2010term exposure to grass pollen adversely associated with lung function and airway inflammation in the community?"],"prefix":"10.1111","volume":"76","author":[{"given":"Nur Sabrina","family":"Idrose","sequence":"first","affiliation":[{"name":"Allergy and Lung Health Unit Melbourne School of Population and Global Health The University of Melbourne Carlton Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel C. 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Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward J.","family":"Newbigin","sequence":"additional","affiliation":[{"name":"School of BioSciences The University of Melbourne Parkville Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mimi L. K.","family":"Tang","sequence":"additional","affiliation":[{"name":"Allergy and Immunology Murdoch Children\u2019s Research Institute Royal Children\u2019s Hospital Melbourne Vic Australia"},{"name":"Department of Pediatrics University of Melbourne Melbourne Vic. 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