{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T13:33:35Z","timestamp":1774359215257,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["FP6\u2010FOOD\u2010CT\u20102005\u2010514000"],"award-info":[{"award-number":["FP6\u2010FOOD\u2010CT\u20102005\u2010514000"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>EAACI guidelines emphasize the importance of patient history in diagnosing food allergy (FA) and the need for studies investigating its value using standardized allergy\u2010focused questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the contribution of reaction characteristics, allergic comorbidities and demographics to prediction of FA in individuals experiencing food\u2010related adverse reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult and school\u2010age participants in the standardized EuroPrevall population surveys, with self\u2010reported FA, were included. Penalized multivariable regression was used to assess the association of patient history determinants with \u201cprobable\u201d FA, defined as a food\u2010specific case history supported by relevant IgE sensitization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In adults (N\u00a0=\u00a0844), reproducibility of reaction (OR 1.35 [95% CI 1.29\u20101.41]), oral allergy symptoms (OAS) (4.46 [4.19\u20104.75]), allergic rhinitis (AR) comorbidity (2.82 [2.68\u20102.95]), asthma comorbidity (1.38 [1.30\u20101.46]) and male sex (1.50 [1.41\u20101.59]) were positively associated with probable FA. Gastrointestinal symptoms (0.88 [0.85\u20100.91]) made probable FA less likely. The AUC of a model combining all selected predictors was 0.85 after cross\u2010validation. In children (N\u00a0=\u00a0670), OAS (2.26 [2.09\u20102.44]) and AR comorbidity (1.47 [CI 1.39\u20101.55]) contributed most to prediction of probable FA, with a combined cross\u2010validation\u2010based AUC of 0.73. When focusing on plant foods, the dominant source of FA in adults, the pediatric model also included gastrointestinal symptoms (inverse association), and the AUC increased to 0.81.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In both adults and school\u2010age children from the general population, reporting of OAS and of AR comorbidity appear to be the strongest predictors of probable FA. Patient history particularly allows for good discrimination between presence and absence of probable plant FA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.14583","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T05:29:42Z","timestamp":1601011782000},"page":"1454-1462","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Predicting food allergy: The value of patient history reinforced"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7128-2699","authenticated-orcid":false,"given":"Sarah A.","family":"Lyons","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 C.","family":"Knulst","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter G. J.","family":"Burney","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute Imperial College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montserrat","family":"Fernandez\u2010Rivas","sequence":"additional","affiliation":[{"name":"Allergy Department Hospital Clinico San Carlos IdISSC ARADyAL, RD16\/0006\/0009 Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara K.","family":"Ballmer\u2010Weber","sequence":"additional","affiliation":[{"name":"Allergy Unit Department of Dermatology University Hospital of Z\u00fcrich Z\u00fcrich Switzerland"},{"name":"Faculty of Medicine University of Z\u00fcrich Z\u00fcrich Switzerland"},{"name":"Clinic for Dermatology and Allergology Kantonsspital St. Gallen St. Gallen Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Barreales","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit Preventive Medicine Department Hospital Clinico San Carlos IdISSC Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Bieli","sequence":"additional","affiliation":[{"name":"Department of Paediatric Pulmonology University Children's Hospital Z\u00fcrich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Clausen","sequence":"additional","affiliation":[{"name":"Children's Hospital Landspitali University Hospital Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruta","family":"Dubakiene","sequence":"additional","affiliation":[{"name":"Medical Faculty Vilnius University Vilnius Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Fernandez\u2010Perez","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit Preventive Medicine Department Hospital Clinico San Carlos IdISSC Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Jedrzejczak\u2010Czechowicz","sequence":"additional","affiliation":[{"name":"Department of Immunology, Rheumatology and Allergy Faculty of Medicine Medical University of Lodz Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8442-2774","authenticated-orcid":false,"given":"Marek L.","family":"Kowalski","sequence":"additional","affiliation":[{"name":"Department of Immunology, Rheumatology and Allergy Faculty of Medicine Medical University of Lodz Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ischa","family":"Kummeling","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute Imperial College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanya","family":"Kralimarkova","sequence":"additional","affiliation":[{"name":"Clinical Centre of Allergology of the Alexandrovska Hospital Medical University of Sofia Sofia Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tihomir B.","family":"Mustakov","sequence":"additional","affiliation":[{"name":"Clinical Centre of Allergology of the Alexandrovska Hospital Medical University of Sofia Sofia Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harmieke","family":"van Os\u2010Medendorp","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Medical Center Utrecht Utrecht The Netherlands"},{"name":"Saxion University of Applied Sciences Deventer The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos G.","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"Allergy Department 2nd Pediatric Clinic University of Athens Athens Greece"},{"name":"Division of Infection, Immunity and Respiratory Medicine University of Manchester Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todor A.","family":"Popov","sequence":"additional","affiliation":[{"name":"University Hospital Sv. Ivan Rilski Sofia Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Potts","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute Imperial College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serge A.","family":"Versteeg","sequence":"additional","affiliation":[{"name":"Department of Experimental Immunology Amsterdam University Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9204-1923","authenticated-orcid":false,"given":"Paraskevi","family":"Xepapadaki","sequence":"additional","affiliation":[{"name":"Allergy Department 2nd Pediatric Clinic University of Athens Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paco M. J.","family":"Welsing","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine and Dermatology University Medical Center Utrecht Utrecht University The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clare","family":"Mills","sequence":"additional","affiliation":[{"name":"Division of Infection, Immunity and Respiratory Medicine Manchester Institute of Biotechnology &amp; Lydia Becker Institute of Immunology and Inflammation University of Manchester Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"van Ree","sequence":"additional","affiliation":[{"name":"Department of Experimental Immunology Amsterdam University Medical Center Amsterdam The Netherlands"},{"name":"Department of Otorhinolaryngology Amsterdam University Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thuy\u2010My","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12341"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.04.020"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.02.044"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12429"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13601-015-0050-2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02046.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.94.07050954"},{"issue":"1","key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.2517-6161.1996.tb02080.x","article-title":"Regression shrinkage and selection via the Lasso","volume":"58","author":"Tibshirani R","year":"1996","journal-title":"J Roy Stat Soc B"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.11.003"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00853.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12924"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1987.tb02317.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12666"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10101520"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.12.004"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2013.07.014"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.14583","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/all.14583","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.14583","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T19:52:51Z","timestamp":1723665171000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.14583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,24]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1111\/all.14583"],"URL":"https:\/\/doi.org\/10.1111\/all.14583","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,24]]},"assertion":[{"value":"2020-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}