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However, the association between SARS\u2010CoV\u20102 and nasal inflammation in chronic rhinosinusitis with nasal polyps (CRSwNP) has not been investigated. We thus investigated the expression of SARS\u2010CoV\u20102 entry factors in nasal tissues of CRSwNP patients, and their associations with inflammatory endotypes of CRSwNP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The expression of ACE2 and TMPRSS2 was assessed in nasal tissues of control subjects and eosinophilic CRSwNP (ECRSwNP) and nonECRSwNP patients. The correlations between ACE2\/TMPRSS2 expression and inflammatory indices of CRSwNP endotypes were evaluated. Regulation of ACE2\/TMPRSS2 expression by inflammatory cytokines and glucocorticoids was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ACE2 expression was significantly increased in nasal tissues of nonECRSwNP patients compared to ECRSwNP patients and control subjects, and positively correlated with the expression of IFN\u2010\u03b3, but negatively correlated with tissue infiltrated eosinophils, and expression of IL5 and IL13. IFN\u2010\u03b3 up\u2010regulated ACE2 expression while glucocorticoid attenuated this increase in cultured nasal epithelial cells. Genes co\u2010expressed with ACE2 were enriched in pathways relating to defence response to virus in nasal tissue. TMPRSS2 expression was decreased in nasal tissues of CRSwNP patients compared to control subjects and not correlated with the inflammatory endotypes of CRSwNP. Glucocorticoid treatment decreased ACE2 expression in nasal tissues of nonECRSwNP patients, but not in ECRSwNP patients, whereas TMPRSS2 expression was not affected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings indicate that ACE2 expression, regulated by IFN\u2010\u03b3, is increased in nasal tissues of nonECRSwNP patients and positively correlates with type 1 inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.14665","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T21:53:11Z","timestamp":1605822791000},"page":"789-803","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Distinct expression of SARS\u2010CoV\u20102 receptor ACE2 correlates with endotypes of chronic rhinosinusitis with nasal polyps"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8560-3964","authenticated-orcid":false,"given":"Ming","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Beijing TongRen Hospital Capital Medical University Beijing China"},{"name":"Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangting","family":"Bu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Beijing TongRen Hospital Capital Medical University Beijing China"},{"name":"Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoli","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Beijing Ditan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Luan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Beijing TongRen Hospital Capital Medical University Beijing China"},{"name":"Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5755-7684","authenticated-orcid":false,"given":"Yanran","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Beijing TongRen Hospital Capital Medical University Beijing China"},{"name":"Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8020-019X","authenticated-orcid":false,"given":"Cezmi 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