{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:08:46Z","timestamp":1791598126172,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,1,3]],"date-time":"2021-01-03T00:00:00Z","timestamp":1609632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014364","name":"National Children's Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Peanut allergy has a rising prevalence in high\u2010income countries, affecting 0.5%\u20131.4% of children. This study aimed to better understand peanut anaphylaxis in comparison to anaphylaxis to other food triggers in European children and adolescents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data was sourced from the European Anaphylaxis Registry via an online questionnaire, after in\u2010depth review of food\u2010induced anaphylaxis cases in a tertiary paediatric allergy centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>3514 cases of food anaphylaxis were reported between July 2007 \u2010 March 2018, 56% in patients younger than 18\u00a0years. Peanut anaphylaxis was recorded in 459 children and adolescents (85% of all peanut anaphylaxis cases). Previous reactions (42% vs. 38%; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001), asthma comorbidity (47% vs. 35%; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), relevant cofactors (29% vs. 22%; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.004) and biphasic reactions (10% vs. 4%; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001) were more commonly reported in peanut anaphylaxis. Most cases were labelled as severe anaphylaxis (Ring&amp;Messmer grade III 65% vs. 56% and grade IV 1.1% vs. 0.9%; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001). Self\u2010administration of intramuscular adrenaline was low (17% vs. 15%), professional adrenaline administration was higher in non\u2010peanut food anaphylaxis (34% vs. 26%; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.003). Hospitalization was higher for peanut anaphylaxis (67% vs. 54%; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The European Anaphylaxis Registry data confirmed peanut as one of the major causes of severe, potentially life\u2010threatening allergic reactions in European children, with some characteristic features e.g., presence of asthma comorbidity and increased rate of biphasic reactions. Usage of intramuscular adrenaline as first\u2010line treatment is low and needs to be improved. The Registry, designed as the largest database on anaphylaxis, allows continuous assessment of this condition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.14683","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T04:16:15Z","timestamp":1607055375000},"page":"1517-1527","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Peanut\u2010induced anaphylaxis in children and adolescents: Data from the European Anaphylaxis Registry"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6734-2329","authenticated-orcid":false,"given":"Ioana","family":"Maris","sequence":"first","affiliation":[{"name":"Bon Secours Hospital Cork\/Paediatrics and Child Health University College Cork Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"D\u00f6lle\u2010Bierke","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology Department of Dermatology, Venereology and Allergology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt\u2010Universit\u00e4t zu Berlin, and Berlin Institute of Health Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Marie","family":"Renaudin","sequence":"additional","affiliation":[{"name":"Allergy Vigilance Network Vandoeuvre les Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Lange","sequence":"additional","affiliation":[{"name":"Department of Paediatrics St. Marien\u2010Hospital Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Koehli","sequence":"additional","affiliation":[{"name":"Division of Allergology University Children\u2019s Hospital Zurich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Spindler","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Medical Campus Hochgebirgsklinik Davos Davos Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Hourihane","sequence":"additional","affiliation":[{"name":"Paediatrics and Child Health Royal College of Surgeons in Ireland Dublin Ireland"},{"name":"Children\u2019s Health Ireland Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Scherer","sequence":"additional","affiliation":[{"name":"Medical Faculty University of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Nemat","sequence":"additional","affiliation":[{"name":"Practice for paediatric pneumology and allergology Kinderzentrum Dresden\u2010Friedrichstadt Dresden 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