{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:16:02Z","timestamp":1785575762542,"version":"3.56.0"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In up to 70%\u201380% of patients with a suspected non\u2010steroidal anti\u2010inflammatory drug hypersensitivity (NSAIDH), challenge tests with the culprit drug yield negative results. On the other hand, there could be a NSAIDH overdiagnosis when anaphylaxis is the clinical manifestation. We hypothesize that some negative NSAID challenge tests and an overdiagnosis of NSAIDH occur in patients with food\u2010dependent NSAID\u2010induced hypersensitivity (FDNIH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 328 patients with a suspected acute NSAIDH. FDNIH was diagnosed in patients meeting all the following: (1) tolerance to the food ingested more temporally closed before the reaction, later the episode, (2) respiratory or cutaneous symptoms or anaphylaxis related to NSAID, (3) positive skin prick test to foods and\/or specific IgE to food allergens (Pru p 3, Tri a 19, Pen a 1) involved in the reaction, and (4) negative oral provocation test to the culprit NSAID.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>199 patients (60%) were diagnosed with NSAIDH and 52 (16%) with FDNIH. Pru p 3 was involved in 44 cases (84.6%) and Tri a 19 in 6 cases (11%). FDNIH subjects were younger (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), with a higher prevalence of rhinitis (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) and previous food allergy (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), together with a higher proportion of subjects sensitized to pollens (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) and foods (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Using just four variables (Pru p 3 sensitization, Tri a 19 sensitization, anaphylaxis, and any NSAID different from pyrazolones), 95.3% of cases were correctly classified, with a sensitivity of 92% and specificity of 96%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Evaluation of FDNIH should be included in the diagnostic workup of NSAIDH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.14689","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T08:26:10Z","timestamp":1607502370000},"page":"1480-1492","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Food\u2010dependent NSAID\u2010induced hypersensitivity (FDNIH) reactions: Unraveling the clinical features and risk factors"],"prefix":"10.1111","volume":"76","author":[{"given":"Jaime","family":"S\u00e1nchez\u2010L\u00f3pez","sequence":"first","affiliation":[{"name":"Department of Pulmonology and Respiratory Allergy Allergy Section Hospital Clinic Barcelona  Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Araujo","sequence":"additional","affiliation":[{"name":"Department of Pulmonology and Respiratory Allergy Allergy Section Hospital Clinic Barcelona  Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2197-9767","authenticated-orcid":false,"given":"Victoria","family":"Cardona","sequence":"additional","affiliation":[{"name":"Department of Internal medicine, Allergy Section Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Vall d'Hebron Research Institute Allergy Research Unit  Barcelona Spain"},{"name":"Spanish Network for Allergy\u2014RETIC de Asma, Reacciones adversas y Al\u00e9rgicas (ARADyAL)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Garc\u00eda\u2010Moral","sequence":"additional","affiliation":[{"name":"Department of Pulmonology and Respiratory Allergy Allergy Section Hospital Clinic Barcelona  Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"Casas\u2010Saucedo","sequence":"additional","affiliation":[{"name":"Department of Pulmonology and Respiratory Allergy Allergy Section Hospital Clinic Barcelona  Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Universitat de Barcelona  Barcelona Spain"},{"name":"Spanish Network for Allergy\u2014RETIC de Asma, Reacciones adversas y Al\u00e9rgicas (ARADyAL)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar","family":"Guilarte","sequence":"additional","affiliation":[{"name":"Department of Internal medicine, Allergy Section Hospital Universitari Vall d'Hebron Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Vall d'Hebron Research Institute Allergy Research Unit  Barcelona Spain"},{"name":"Spanish Network for Allergy\u2014RETIC de Asma, Reacciones adversas y Al\u00e9rgicas (ARADyAL)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5228-471X","authenticated-orcid":false,"given":"Mar\u00eda Jos\u00e9","family":"Torres","sequence":"additional","affiliation":[{"name":"Spanish Network for Allergy\u2014RETIC de Asma, Reacciones adversas y Al\u00e9rgicas (ARADyAL)  Madrid Spain"},{"name":"Allergy Unit Hospital Regional Universitario de M\u00e1laga  Malaga Spain"},{"name":"Allergy Research Group Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga\u2010IBIMA  Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5309-4878","authenticated-orcid":false,"given":"Inmaculada","family":"Do\u00f1a","sequence":"additional","affiliation":[{"name":"Spanish Network for Allergy\u2014RETIC de Asma, Reacciones adversas y Al\u00e9rgicas (ARADyAL)  Madrid Spain"},{"name":"Allergy Unit Hospital Regional Universitario de M\u00e1laga  Malaga Spain"},{"name":"Allergy Research Group Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga\u2010IBIMA  Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7400-4993","authenticated-orcid":false,"given":"Cesar","family":"Picado","sequence":"additional","affiliation":[{"name":"Department of Pulmonology and Respiratory Allergy Allergy Section Hospital Clinic Barcelona  Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Universitat de Barcelona  Barcelona Spain"},{"name":"CIBERES CIBER of Respiratory Diseases  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0549-9720","authenticated-orcid":false,"given":"Mariona","family":"Pascal","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Universitat de Barcelona  Barcelona Spain"},{"name":"Spanish Network for Allergy\u2014RETIC de Asma, Reacciones adversas y Al\u00e9rgicas (ARADyAL)  Madrid Spain"},{"name":"Immunology Department Centre de Diagn\u00f2stic Biom\u00e8dic (CDB) Hospital Cl\u00ednic de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8566-8285","authenticated-orcid":false,"given":"Rosa","family":"Mu\u00f1oz\u2010Cano","sequence":"additional","affiliation":[{"name":"Department of Pulmonology and Respiratory Allergy Allergy Section Hospital Clinic Barcelona  Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Universitat de Barcelona  Barcelona Spain"},{"name":"Spanish Network for Allergy\u2014RETIC de Asma, Reacciones adversas y Al\u00e9rgicas (ARADyAL)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7767-4730","authenticated-orcid":false,"given":"Joan","family":"Bartra","sequence":"additional","affiliation":[{"name":"Department of Pulmonology and Respiratory Allergy Allergy Section Hospital Clinic Barcelona  Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Universitat de Barcelona  Barcelona Spain"},{"name":"Spanish Network for Allergy\u2014RETIC de Asma, Reacciones adversas y Al\u00e9rgicas (ARADyAL)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02557.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12260"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000337660"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2016.10.004"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000438992"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12689"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13601-015-0052-0"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03648.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12423"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.02.044"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12272"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12418"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2007.02682.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000354543"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.05.013"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02795.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12193"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13207"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-4079(19)32589-0"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2009.03709.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02877.x."},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2012.04071.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2016.61608"},{"key":"e_1_2_9_25_1","first-page":"3","article-title":"Possible interaction among hypersensitivity to lipid transfer proteins, chronic urticaria, and hypersensitivity reactions to nonsteroidal anti\u2010inflammatory drugs","volume":"43","author":"Romano A","year":"2011","journal-title":"Allergy"},{"issue":"2","key":"e_1_2_9_26_1","first-page":"113","article-title":"Prawns, barnacles, and nonsteroidal anti\u2010inflammatory drugs: effect modifiers or diagnostic confounders","volume":"17","author":"Vidal C","year":"2007","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.02213.x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2003.00136.x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.105011"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.288.6419.755"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13151"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000446156"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.5415\/apallergy.2016.6.2.129"},{"key":"e_1_2_9_34_1","first-page":"193","article-title":"Molecular allergology in practice: an unusual case of LTP allergy","volume":"43","author":"Metz\u2010Favre C","year":"2011","journal-title":"Allergy"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.10.009"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1159\/000102612"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.06.016"},{"key":"e_1_2_9_38_1","first-page":"9","article-title":"Proposed new mechanism for food and exercise induced anaphylaxis based on case studies","volume":"20","author":"Chen JY","year":"2013","journal-title":"Allergy Asthma Clin Immunol"},{"key":"e_1_2_9_39_1","first-page":"278","article-title":"Prevalence of sensitization to lipid transfer proteins and profilins in a population of 430 patients in the south of Madrid","volume":"21","author":"Gonz\u00e1lez\u2010Mancebo E","year":"2011","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12640"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12735"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04601.x"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13026"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03651.x"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00503"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13747"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.08.024"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.12-OA-0495"}],"container-title":["Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.14689","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/all.14689","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/all.14689","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T11:50:58Z","timestamp":1693223458000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/all.14689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,22]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1111\/all.14689"],"URL":"https:\/\/doi.org\/10.1111\/all.14689","archive":["Portico"],"relation":{},"ISSN":["0105-4538","1398-9995"],"issn-type":[{"value":"0105-4538","type":"print"},{"value":"1398-9995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,22]]},"assertion":[{"value":"2020-01-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}