{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:18:28Z","timestamp":1790745508369,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,12,26]],"date-time":"2020-12-26T00:00:00Z","timestamp":1608940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Biologic agents (also termed biologics or biologicals) are becoming increasingly important in the treatment of immune\u2010mediated diseases. However, the diversity of clinical trials along with the fast pace of publication makes it difficult to determine the level of evidence for the use of a biologic for a given disorder. To address this challenge, we are publishing a series of systematic reviews evaluating the safety and efficacy of B cell\u2013targeting biologics for the treatment of immune\u2010mediated diseases. In this article, we have assessed the safety and efficacy of belimumab, a fully human IgG1 monoclonal antibody targeting the cytokine B cell\u2013activating factor (BAFF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate belimumab's safety and efficacy for the treatment of immune\u2010mediated disorders compared to placebo, conventional treatment or other biologics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Preferred Reporting Items for Systematic reviews and Meta\u2010Analyses (PRISMA) checklist guided the reporting of the data. We searched the PubMed database between October 4, 2016, and June 23, 2019, concentrating on immune\u2010mediated disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The literature search identified 583 articles. After screening titles and abstracts against the inclusion and exclusion criteria and assessing full texts, 17 articles were finally included in a narrative synthesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Belimumab is both safe and effective for the treatment of systemic lupus erythematosus. Results were further promising for the use of belimumab in patients with rheumatoid arthritis and Sj\u00f6gren\u2019s syndrome. Conversely, results using belimumab in patients with anti\u2010neutrophil cytoplasmic antibody (ANCA)\u2010associated vasculitis and myasthenia gravis were rather disappointing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.14704","type":"journal-article","created":{"date-parts":[[2020,12,27]],"date-time":"2020-12-27T07:05:50Z","timestamp":1609052750000},"page":"2673-2683","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Systematic review of safety and efficacy of belimumab in treating immune\u2010mediated disorders"],"prefix":"10.1111","volume":"76","author":[{"given":"Celine","family":"Kaegi","sequence":"first","affiliation":[{"name":"Department of Immunology University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urs C.","family":"Steiner","sequence":"additional","affiliation":[{"name":"Department of Immunology University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Wuest","sequence":"additional","affiliation":[{"name":"Department of Immunology University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Crowley","sequence":"additional","affiliation":[{"name":"Department of Immunology University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8279-5545","authenticated-orcid":false,"given":"Onur","family":"Boyman","sequence":"additional","affiliation":[{"name":"Department of Immunology University Hospital Zurich Zurich Switzerland"},{"name":"Faculty of Medicine University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1100030"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.123"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01990"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00433"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.33"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02698"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.52.6.377"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40802"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005323"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.120886"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203991"},{"issue":"12","key":"e_1_2_8_14_1","first-page":"2249","article-title":"Efficacy and safety of belimumab given for 12 months in primary Sjogren's syndrome: the BELISS open\u2010label phase II study","volume":"54","author":"De Vita S","year":"2015","journal-title":"Rheumatology"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/21556660.2013.792823"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30613"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61354-2"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40049"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211631"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2506"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24699"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.121368"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34564"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203318777634"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40439"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40861"},{"key":"e_1_2_8_27_1","unstructured":"A Multi\u2010Center Open\u2010Label Continuation Trial of LymphoStat\u2010B Antibody (Monoclonal Anti\u2010BLyS Antibody) in Subjects With Rheumatoid Arthritis (RA) Who Completed the Phase 2 Procotol LBRA01. Clinicaltrials.gov.https:\/\/clinicaltrials.gov\/ct2\/show\/study\/NCT00583557?term=belimumab&cond=rheumatoid+arthritis&draw=2&rank=1. Accessed September 7 2020."},{"key":"e_1_2_8_28_1","unstructured":"An Expanded Acces Trial of Belimumab Antibody (Monoclonal Anti\u2010BLyS Antibody) in Patients with Rheumatoid Arthritis (RA) Who Were Previously Treated Under HGS Procotol LBRA99. Clinicaltrials.gov.https:\/\/clinicaltrials.gov\/ct2\/show\/study\/NCT00931086?term=belimumab&cond=rheumatoid+arthritis&draw=2&rank=2. Accessed September 7 2020"},{"key":"e_1_2_8_29_1","unstructured":"A Randomized Double Blind (Sponsor Open) Comparative Multicenter Study to Evaluate the Safety and Efficacy of Subcutaneous Belimumab (GSK1550188) and Intravenous Rituximab Co\u2010administration in Subjects With Primary Sj\u00f6gren's Syndrome. Clinicaltrials.gov.https:\/\/clinicaltrials.gov\/ct2\/show\/study\/NCT02631538?term=belimumab&cond=Sjogren%27s+Syndrome&draw=2&rank=3. 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