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Whereas cross\u2010linking of IgE on Fc\u03b5RI expressed by mast cells and basophils triggers the allergic reaction, binding of IgE to CD23 on B cells plays an important role in both IgE regulation and presentation. Furthermore, IgE\u2010immune complexes (IgE\u2010ICs) bound by B cells enhance antibody and T cell responses in mice and humans. However, the mechanisms that regulate the targeting of the two receptors and the respective function of the two pathways in inflammation or homeostasis are still a matter of debate. Here, we focus on CD23 and discuss several mechanisms related to IgE binding, as well as the impact of the IgE\/antigen\u2010binding on different immune cells expressing CD23. One recent paper has shown that free IgE preferentially binds to Fc\u03b5RI whereas IgE\u2010ICs are preferentially captured by CD23. Binding of IgE\u2010ICs to CD23 on B cells can, on one hand, regulate serum IgE and prevent effector cell activation and on the other hand facilitate antigen presentation by delivering the antigen to dendritic cells. These data argue for a multifunctional role of CD23 for modulating IgE serum levels and immune responses.<\/jats:p>","DOI":"10.1111\/all.14724","type":"journal-article","created":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T01:08:00Z","timestamp":1609376880000},"page":"1981-1989","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["The role of CD23 in the regulation of allergic responses"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3409-512X","authenticated-orcid":false,"given":"Paul","family":"Engeroff","sequence":"first","affiliation":[{"name":"INSERM UMR_S 959 Immunology\u2010Immunopathology\u2010Immunotherapy (i3) Sorbonne Universit\u00e9 Paris 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