{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:19:38Z","timestamp":1792523978589,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,7,18]],"date-time":"2021-07-18T00:00:00Z","timestamp":1626566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pollen food allergy syndrome (PFAS) is a frequently underdiagnosed disease due to diverse triggers, clinical presentations, and test results. This is especially relevant in geographic areas with a broad spectrum of pollen sensitization, such as Southern Europe.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To elucidate similarities and differences of PFAS in nine Southern European centers and identify associated characteristics and unique markers of PFAS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>As part of the @IT.2020\u00a0Multicenter Study, 815 patients with seasonal allergic rhinitis (SAR), aged 10\u201360\u00a0years, were recruited in seven countries. They completed questionnaires regarding SAR, comorbidities, family history, and PFAS, and underwent skin prick testing (SPT) and serum IgE testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 815 patients, 167 (20.5%) reported PFAS reactions. Most commonly, eliciting foods were kiwi (58, 34.7%), peach (43, 25.7%), and melon (26, 15.6%). Reported reactions were mostly local (216\/319, 67.7%), occurring within 5\u00a0min of contact with elicitors (209\/319, 65.5%). Associated characteristics included positive IgE to at least one panallergen (profilin, PR\u201010, or nsLTP) (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.007), maternal PFAS (OR: 3.716, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.026), and asthma (OR: 1.752, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.073). Between centers, heterogeneity in prevalence (Marseille: 7.5% vs. Rome: 41.4%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and of clinical characteristics was apparent. Cypress played a limited role, with only 1\/22 SPT mono\u2010sensitized patients reporting a food reaction (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.073).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PFAS is a frequent comorbidity in Southern European SAR patients. Significant heterogeneity of clinical characteristics in PFAS patients among the centers was observed and may be related to the different pollen sensitization patterns in each geographic area. IgE to panallergen(s), maternal PFAS, and asthma could be PFAS\u2010associated characteristics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.14742","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T20:13:22Z","timestamp":1611605602000},"page":"3041-3052","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Heterogeneity of pollen food allergy syndrome in seven Southern European countries: The @IT.2020 multicenter study"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6808-5942","authenticated-orcid":false,"given":"Theresa","family":"Lipp","sequence":"first","affiliation":[{"name":"Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aydan","family":"Acar 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