{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:19:55Z","timestamp":1789589995775,"version":"build-2803163510"},"reference-count":68,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T00:00:00Z","timestamp":1616198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objective<\/jats:title>\n                    <jats:p>As the rise in prevalence of allergic diseases worldwide corresponds in time with increasing infant vaccination, it has been hypothesized that childhood vaccination may increase the risk of allergic disease. We aimed to synthesize the literature on the association between childhood vaccination and allergy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>We searched the electronic databases PubMed and EMBASE (January 1946\u2010January 2018) using vaccination and allergy terms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two authors selected papers according to the inclusion criteria. Pooled effects across studies were estimated using random\u2010effects meta\u2010analysis. Due to inadequate number of homogeneous publications on newer and underused vaccines, meta\u2010analysis was limited to allergic outcomes following administration of (Bacillus Calmette\u2010Gu\u00e9rin) BCG, measles or pertussis vaccination. The review was prospectively registered in the PROSPERO systematic review registry (NO: CRD42017071009).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 35 publications based on cohort studies and 7 publications based on randomized controlled trials (RCTs) met the inclusion criteria. RCTs: From 2 studies, early vaccination with BCG vaccine was associated with a reduced risk of eczema (RR\u00a0=\u00a00.83; 95% CI\u00a0=\u00a00.73\u20100.93;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00%) but not food allergy or asthma. No association was found between pertussis vaccine and any allergic outcome based on a single RCT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Cohort studies<\/jats:title>\n                    <jats:p>\n                      Childhood measles vaccination was associated with a reduced risk of eczema (RR\u00a0=\u00a00.65; 95% CI\u00a0=\u00a00.47\u20100.90,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.0%), asthma (RR\u00a0=\u00a00.78; 95% CI\u00a0=\u00a00.62\u20100.98,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a093.9%) and, with a similar, statistically non\u2010significant reduction in sensitization (RR\u00a0=\u00a00.78; 95% CI\u00a0=\u00a00.61\u20101.01,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a019.4%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found no evidence that childhood vaccination with commonly administered vaccines was associated with increased risk of later allergic disease. Our results from pooled analysis of both RCTs and cohort studies suggest that vaccination with BCG and measles vaccines were associated with a reduced risk of eczema.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.14771","type":"journal-article","created":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T19:17:57Z","timestamp":1613243877000},"page":"2135-2152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Childhood vaccination and allergy: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8528-9891","authenticated-orcid":false,"given":"Samidi","family":"Navaratna","sequence":"first","affiliation":[{"name":"Faculty of Medicine Department of Community Medicine University of Peradeniya Kandy Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie J.","family":"Estcourt","sequence":"additional","affiliation":[{"name":"Wesfarmers Centre of Vaccines &amp; Infectious Diseases Telethon Kids Institute Perth Children's Hospital Nedlands Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7532-5027","authenticated-orcid":false,"given":"John","family":"Burgess","sequence":"additional","affiliation":[{"name":"Allergy and Lung Health Unit Centre for Epidemiology and Biostatistics Melbourne School of Population and Global Health The University of Melbourne Parkville Vic. 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