{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:07:23Z","timestamp":1790615243066,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T00:00:00Z","timestamp":1617753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Allergy, the most frequent immune disorder affecting 30% of the world's population, is the consequence of immunoglobin E (IgE) sensitization to allergens. Among the genetic factors suspected to be involved in allergy, the HLA class\u2010II genomic region is a strong candidate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the association between HLA class\u2010II alleles and specific IgE (sIgE) sensitization to a large number of respiratory allergen molecules.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The analysis relied on 927 participants of the EGEA cohort, including 497 asthmatics. The study focuses on 26 aeroallergens recognized by sIgE in at least 5% of the study population (determined with the MEDALL chip with sIgE\u00a0\u2265\u00a00.3 ISU) and 23 imputed HLA class\u2010II alleles. For each sIgE sensitization and HLA class\u2010II allele, we fitted a logistic regression model accounting for familial dependence and adjusted for gender, age, and genetic principal components. <jats:italic>p<\/jats:italic>\u2010values were corrected for multiple comparisons (False Discovery Rate).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most of the 19 statistically significant associations observed regard pollen allergens (mugwort Art v 1, olive tree Ole e 1, timothy grass Phl p 2, Phl p 5 and plantain Pla l 1), three were mold allergen (<jats:italic>Alternaria<\/jats:italic> Alt a 1), and a single one regards house dust mite allergen (Der p 7). No association was observed with pet allergens. The strongest associations were found with mugwort Art v 1 (OR\u00a0=\u00a05.42 (95%CI, 3.30; 8.88), 4.14 (2.65; 6.47), 3.16 (1.88; 5.31) with DQB1*05:01, DQA1*01:01 and DRB1*01:01, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results support the important role of HLA class\u2010II alleles as immune response genes predisposing their carriers for sensitization to various major pollen allergens.<\/jats:p><\/jats:sec>","DOI":"10.1111\/all.14820","type":"journal-article","created":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T01:36:39Z","timestamp":1616204199000},"page":"2575-2586","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Associations between specific IgE sensitization to 26 respiratory allergen molecules and HLA class II alleles in the EGEA cohort"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2375-3059","authenticated-orcid":false,"given":"Hubert","family":"Gheerbrant","sequence":"first","affiliation":[{"name":"Service Hospitalier Universitaire Pneumologie Physiologie Centre Hospitalier Universitaire Grenoble Alpes  Grenoble France"},{"name":"Inserm CNRS IAB Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health University Grenoble Alpes  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Guillien","sequence":"additional","affiliation":[{"name":"Inserm CNRS IAB Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health University Grenoble Alpes  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00ebl","family":"Vernet","sequence":"additional","affiliation":[{"name":"UMRS 1124 INSERM Group of Genomic Epidemiology of Multifactorial Diseases Universit\u00e9 de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Lupinek","sequence":"additional","affiliation":[{"name":"Division of Immunopathology Department of Pathophysiology and Allergy Research Center for Pathophysiology, Infectiology and Immunology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Pison","sequence":"additional","affiliation":[{"name":"Service Hospitalier Universitaire Pneumologie Physiologie Centre Hospitalier Universitaire Grenoble Alpes  Grenoble France"},{"name":"Inserm 1055 Laboratoire de Bio\u00e9nerg\u00e9tique Fondamentale et Appliqu\u00e9e  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Pin","sequence":"additional","affiliation":[{"name":"Inserm CNRS IAB Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health University Grenoble Alpes  Grenoble France"},{"name":"Department of Pediatrics Grenoble\u2010Alpes University Hospital  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Demenais","sequence":"additional","affiliation":[{"name":"UMRS 1124 INSERM Group of Genomic Epidemiology of Multifactorial Diseases Universit\u00e9 de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Nadif","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay UVSQ Univ. Paris\u2010Sud Inserm \u00c9quipe d'\u00c9pid\u00e9miologie respiratoire int\u00e9grative CESP  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Bousquet","sequence":"additional","affiliation":[{"name":"Arnaud de Villeneuve University Hospital and Inserm  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winfried F.","family":"Pickl","sequence":"additional","affiliation":[{"name":"Institute of Immunology Center for Pathophysiology, Infectiology and Immunology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Valenta","sequence":"additional","affiliation":[{"name":"Division of Immunopathology Department of Pathophysiology and Allergy Research Center for Pathophysiology, Infectiology and Immunology Medical University of Vienna  Vienna Austria"},{"name":"NRC Institute of Immunology FMBA of Russia  Moscow 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