{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:09:18Z","timestamp":1791655758217,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T00:00:00Z","timestamp":1620604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008477","name":"Buckeye Career Center Foundation","doi-asserted-by":"publisher","award":["K08DK097721"],"award-info":[{"award-number":["K08DK097721"]}],"id":[{"id":"10.13039\/100008477","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Allergy"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Esophageal histology is critical for diagnosis and surveillance of disease activity in eosinophilic esophagitis (EoE). A validated noninvasive biomarker has not been identified. We aimed to determine the utility of blood and urine eosinophil\u2010associated proteins to diagnose EoE and predict esophageal eosinophilia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Blood and urine were collected from children undergoing endoscopy with biopsy. Absolute eosinophil count (AEC), plasma eosinophil\u2010derived neurotoxin (EDN), eosinophil cationic protein (ECP), major basic protein\u20101 (MBP\u20101), galectin\u201010 (CLC\/GAL\u201010), Eotaxin\u20102 and Eotaxin\u20103, and urine osteopontin (OPN) and matrix metalloproteinase\u20109 (MMP\u20109) were determined. Differences were assessed between EoE and control, and with treatment response. The capacity to predict EoE diagnosis and esophageal eosinophil counts was assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 183 specimens were collected from 56 EoE patients and 15 non\u2010EoE controls with symptoms of esophageal dysfunction; 33 EoE patients had paired pre\u2010 and post\u2010treatment specimens. Plasma (CLC\/GAL\u201010, ECP, EDN, Eotaxin\u20103, MBP\u20101) and urine (OPN) biomarkers were increased in EoE compared to control. A panel comprising CLC\/GAL\u201010, Eotaxin\u20103, ECP, EDN, MBP\u20101, and AEC was superior to AEC alone in distinguishing EoE from control. AEC, CLC\/GAL\u201010, ECP, and MBP\u20101 were significantly decreased in patients with esophageal eosinophil counts &lt;15\/hpf in response to treatment. AEC, CLC\/GAL\u201010, ECP, EDN, OPN, and MBP\u20101 each predicted esophageal eosinophil counts utilizing mixed models controlled for age, gender, treatment, and atopy; AEC combined with MBP\u20101 best predicted the counts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We identified novel panels of eosinophil\u2010associated proteins that along with AEC are superior to AEC alone in distinguishing EoE from controls and predicting esophageal eosinophil counts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/all.14874","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T13:45:57Z","timestamp":1619531157000},"page":"3755-3765","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Noninvasive biomarkers identify eosinophilic esophagitis: A prospective longitudinal study in children"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1275-3275","authenticated-orcid":false,"given":"Joshua B.","family":"Wechsler","sequence":"first","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Chicago IL USA"},{"name":"Department of Pediatrics Division of Gastroenterology, Hepatology, and Nutrition Eosinophilic Gastrointestinal Diseases Program Ann &amp; Robert H. Lurie Children's Hospital of Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8183-4693","authenticated-orcid":false,"given":"Steven J.","family":"Ackerman","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics University of Illinois\u2010Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7177-2791","authenticated-orcid":false,"given":"Mirna","family":"Chehade","sequence":"additional","affiliation":[{"name":"Mount Sinai Center for Eosinophilic Disorders Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Amsden","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Gastroenterology, Hepatology, and Nutrition Eosinophilic Gastrointestinal Diseases Program Ann &amp; Robert H. Lurie Children's Hospital of Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Riffle","sequence":"additional","affiliation":[{"name":"Mount Sinai Center for Eosinophilic Disorders Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Gastroenterology, Hepatology, and Nutrition Eosinophilic Gastrointestinal Diseases Program Ann &amp; Robert H. Lurie Children's Hospital of Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics University of Illinois\u2010Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt L.","family":"Kleinjan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics University of Illinois\u2010Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeth","family":"Alumkal","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Genetics University of Illinois\u2010Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9298-6927","authenticated-orcid":false,"given":"Elizabeth","family":"Gray","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Chicago IL USA"},{"name":"Department of Preventive Medicine Feinberg School of Medicine Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4168-757X","authenticated-orcid":false,"given":"Kwang\u2010Youn A.","family":"Kim","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Chicago IL USA"},{"name":"Department of Preventive Medicine Feinberg School of Medicine Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry K.","family":"Wershil","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Chicago IL USA"},{"name":"Department of Pediatrics Division of Gastroenterology, Hepatology, and Nutrition Eosinophilic Gastrointestinal Diseases Program Ann &amp; Robert H. 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