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Mast cells are important for homeostasis and surveillance of the human system, recognizing both endogenous and exogenous agents, which induce release of a variety of mediators acting on both immune and non\u2010immune cells, including nerve cells, fibroblasts, endothelial cells, smooth muscle cells, and epithelial cells. During recent years, clinical and experimental studies on human mast cells, as well as experiments using animal models, have resulted in many discoveries that help decipher the function of mast cells in health and disease. In this review, we focus particularly on new insights into mast cell biology, with a focus on mast cell development, recruitment, heterogeneity, and reactivity. We also highlight the development in our understanding of mast cell\u2010driven diseases and discuss the development of novel strategies to treat such conditions.<\/jats:p>","DOI":"10.1111\/all.14881","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T22:32:36Z","timestamp":1620340356000},"page":"83-99","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":147,"title":["The ingenious mast cell: Contemporary insights into mast cell behavior and function"],"prefix":"10.1111","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3007-9875","authenticated-orcid":false,"given":"Joakim S.","family":"Dahlin","sequence":"first","affiliation":[{"name":"Division of Immunology and Allergy Department of Medicine Karolinska Institutet Karolinska University Hospital Stockholm 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